Hepatitis C virus to hepatocellular carcinoma

Hepatitis C virus causes acute and chronic hepatitis and can lead to permanent liver damage and hepatocellular carcinoma (HCC) in a significant number of patients via oxidative stress, insulin resistance (IR), fibrosis, liver cirrhosis and HCV induced steatosis. HCV induced steatosis and oxidative s...

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Autores principales: Jahan, Shah, Ashfaq, Usman A, Qasim, Muhammad, Khaliq, Saba, Saleem, Muhammad Javed, Afzal, Nadeem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293064/
https://www.ncbi.nlm.nih.gov/pubmed/22289144
http://dx.doi.org/10.1186/1750-9378-7-2
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author Jahan, Shah
Ashfaq, Usman A
Qasim, Muhammad
Khaliq, Saba
Saleem, Muhammad Javed
Afzal, Nadeem
author_facet Jahan, Shah
Ashfaq, Usman A
Qasim, Muhammad
Khaliq, Saba
Saleem, Muhammad Javed
Afzal, Nadeem
author_sort Jahan, Shah
collection PubMed
description Hepatitis C virus causes acute and chronic hepatitis and can lead to permanent liver damage and hepatocellular carcinoma (HCC) in a significant number of patients via oxidative stress, insulin resistance (IR), fibrosis, liver cirrhosis and HCV induced steatosis. HCV induced steatosis and oxidative stress causes steato-hepatitis and these pathways lead to liver injury or HCC in chronic HCV infection. Steatosis and oxidative stress crosstalk play an important role in liver damage in HCV infection. This Review illustrates viral and host factors which induce Oxidative stress, steatosis and leads toward HCC. It also expresses Molecular cascade which leads oxidative stress and steatosis to HCC.
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spelling pubmed-32930642012-03-05 Hepatitis C virus to hepatocellular carcinoma Jahan, Shah Ashfaq, Usman A Qasim, Muhammad Khaliq, Saba Saleem, Muhammad Javed Afzal, Nadeem Infect Agent Cancer Review Hepatitis C virus causes acute and chronic hepatitis and can lead to permanent liver damage and hepatocellular carcinoma (HCC) in a significant number of patients via oxidative stress, insulin resistance (IR), fibrosis, liver cirrhosis and HCV induced steatosis. HCV induced steatosis and oxidative stress causes steato-hepatitis and these pathways lead to liver injury or HCC in chronic HCV infection. Steatosis and oxidative stress crosstalk play an important role in liver damage in HCV infection. This Review illustrates viral and host factors which induce Oxidative stress, steatosis and leads toward HCC. It also expresses Molecular cascade which leads oxidative stress and steatosis to HCC. BioMed Central 2012-01-30 /pmc/articles/PMC3293064/ /pubmed/22289144 http://dx.doi.org/10.1186/1750-9378-7-2 Text en Copyright ©2012 Jahan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Jahan, Shah
Ashfaq, Usman A
Qasim, Muhammad
Khaliq, Saba
Saleem, Muhammad Javed
Afzal, Nadeem
Hepatitis C virus to hepatocellular carcinoma
title Hepatitis C virus to hepatocellular carcinoma
title_full Hepatitis C virus to hepatocellular carcinoma
title_fullStr Hepatitis C virus to hepatocellular carcinoma
title_full_unstemmed Hepatitis C virus to hepatocellular carcinoma
title_short Hepatitis C virus to hepatocellular carcinoma
title_sort hepatitis c virus to hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293064/
https://www.ncbi.nlm.nih.gov/pubmed/22289144
http://dx.doi.org/10.1186/1750-9378-7-2
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AT khaliqsaba hepatitiscvirustohepatocellularcarcinoma
AT saleemmuhammadjaved hepatitiscvirustohepatocellularcarcinoma
AT afzalnadeem hepatitiscvirustohepatocellularcarcinoma

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