Neuro-inflammation, blood-brain barrier, seizures and autism

Many children with Autism Spectrum Diseases (ASD) present with seizure activity, but the pathogenesis is not understood. Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress trigger...

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Detalles Bibliográficos
Autores principales: Theoharides, Theoharis C, Zhang, Bodi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293070/
https://www.ncbi.nlm.nih.gov/pubmed/22129087
http://dx.doi.org/10.1186/1742-2094-8-168
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author Theoharides, Theoharis C
Zhang, Bodi
author_facet Theoharides, Theoharis C
Zhang, Bodi
author_sort Theoharides, Theoharis C
collection PubMed
description Many children with Autism Spectrum Diseases (ASD) present with seizure activity, but the pathogenesis is not understood. Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead to focal disruption of the blood-brain barrier and neuro-inflammation, thus contributing to the development of seizures. Treating neuro-inflammation may be useful when anti-seizure medications are ineffective.
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spelling pubmed-32930702012-03-05 Neuro-inflammation, blood-brain barrier, seizures and autism Theoharides, Theoharis C Zhang, Bodi J Neuroinflammation Hypothesis Many children with Autism Spectrum Diseases (ASD) present with seizure activity, but the pathogenesis is not understood. Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead to focal disruption of the blood-brain barrier and neuro-inflammation, thus contributing to the development of seizures. Treating neuro-inflammation may be useful when anti-seizure medications are ineffective. BioMed Central 2011-11-30 /pmc/articles/PMC3293070/ /pubmed/22129087 http://dx.doi.org/10.1186/1742-2094-8-168 Text en Copyright ©2011 Theoharides and Zhang; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis
Theoharides, Theoharis C
Zhang, Bodi
Neuro-inflammation, blood-brain barrier, seizures and autism
title Neuro-inflammation, blood-brain barrier, seizures and autism
title_full Neuro-inflammation, blood-brain barrier, seizures and autism
title_fullStr Neuro-inflammation, blood-brain barrier, seizures and autism
title_full_unstemmed Neuro-inflammation, blood-brain barrier, seizures and autism
title_short Neuro-inflammation, blood-brain barrier, seizures and autism
title_sort neuro-inflammation, blood-brain barrier, seizures and autism
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293070/
https://www.ncbi.nlm.nih.gov/pubmed/22129087
http://dx.doi.org/10.1186/1742-2094-8-168
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