Cargando…

Relevance of Serum Levels of Interleukin-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma

Syndecan-1 is a trans-membrane heparan sulfate proteoglycan that localizes in epithelial cells and has been shown to be present in normal hepatocytes. It is thought to be involved in processes such as cell growth, differentiation and adhesion. However, the clinical data regarding syndecan-1 in patie...

Descripción completa

Detalles Bibliográficos
Autores principales: Metwaly, Heba A., Al-Gayyar, Mohammed M. H., Eletreby, Shahira, Ebrahim, Mohamed A., El-Shishtawy, Mamdouh M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293347/
https://www.ncbi.nlm.nih.gov/pubmed/22396913
http://dx.doi.org/10.3797/scipharm.1110-07
_version_ 1782225385478422528
author Metwaly, Heba A.
Al-Gayyar, Mohammed M. H.
Eletreby, Shahira
Ebrahim, Mohamed A.
El-Shishtawy, Mamdouh M.
author_facet Metwaly, Heba A.
Al-Gayyar, Mohammed M. H.
Eletreby, Shahira
Ebrahim, Mohamed A.
El-Shishtawy, Mamdouh M.
author_sort Metwaly, Heba A.
collection PubMed
description Syndecan-1 is a trans-membrane heparan sulfate proteoglycan that localizes in epithelial cells and has been shown to be present in normal hepatocytes. It is thought to be involved in processes such as cell growth, differentiation and adhesion. However, the clinical data regarding syndecan-1 in patients with hepatocellular carcinoma (HCC) are scarce and controversial. Therefore, we need to evaluate the effects of HCC on the serum levels of syndecan-1. Thus, 40 patients with HCC and 31 patients with liver cirrhosis were physically examined. Blood samples were taken for measurements of routine markers (sGPT, sGOT, bilirubin, albumin, and α-fetoprotein), as well as serum levels of interleukin (IL)-6 and syndecan-1. Patients with liver cirrhosis showed significant increase in serum IL-6 as compared with HCC patients and the control subjects. Serum level of syndecan-1 was significantly increased in HCC patients as compared with the cirrhotic and control groups. In addition, significant positive correlations between syndecan-1 and serum levels of ALT, AST in HCC patients were found. Moreover, syndecan-1 increased significantly with increasing stage of Barcelona-Clinic Liver Cancer Group diagnostic and treatment strategy. In conclusion, the development of HCC is accompanied by a significant elevation in serum syndecan-1 levels. The increase in serum syndecan-1 may be linked with progression of HCC.
format Online
Article
Text
id pubmed-3293347
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Österreichische Apotheker-Verlagsgesellschaft
record_format MEDLINE/PubMed
spelling pubmed-32933472012-03-06 Relevance of Serum Levels of Interleukin-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma Metwaly, Heba A. Al-Gayyar, Mohammed M. H. Eletreby, Shahira Ebrahim, Mohamed A. El-Shishtawy, Mamdouh M. Sci Pharm Research Article Syndecan-1 is a trans-membrane heparan sulfate proteoglycan that localizes in epithelial cells and has been shown to be present in normal hepatocytes. It is thought to be involved in processes such as cell growth, differentiation and adhesion. However, the clinical data regarding syndecan-1 in patients with hepatocellular carcinoma (HCC) are scarce and controversial. Therefore, we need to evaluate the effects of HCC on the serum levels of syndecan-1. Thus, 40 patients with HCC and 31 patients with liver cirrhosis were physically examined. Blood samples were taken for measurements of routine markers (sGPT, sGOT, bilirubin, albumin, and α-fetoprotein), as well as serum levels of interleukin (IL)-6 and syndecan-1. Patients with liver cirrhosis showed significant increase in serum IL-6 as compared with HCC patients and the control subjects. Serum level of syndecan-1 was significantly increased in HCC patients as compared with the cirrhotic and control groups. In addition, significant positive correlations between syndecan-1 and serum levels of ALT, AST in HCC patients were found. Moreover, syndecan-1 increased significantly with increasing stage of Barcelona-Clinic Liver Cancer Group diagnostic and treatment strategy. In conclusion, the development of HCC is accompanied by a significant elevation in serum syndecan-1 levels. The increase in serum syndecan-1 may be linked with progression of HCC. Österreichische Apotheker-Verlagsgesellschaft 2012 2011-12-23 /pmc/articles/PMC3293347/ /pubmed/22396913 http://dx.doi.org/10.3797/scipharm.1110-07 Text en © Metwaly et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Metwaly, Heba A.
Al-Gayyar, Mohammed M. H.
Eletreby, Shahira
Ebrahim, Mohamed A.
El-Shishtawy, Mamdouh M.
Relevance of Serum Levels of Interleukin-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma
title Relevance of Serum Levels of Interleukin-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma
title_full Relevance of Serum Levels of Interleukin-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma
title_fullStr Relevance of Serum Levels of Interleukin-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma
title_full_unstemmed Relevance of Serum Levels of Interleukin-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma
title_short Relevance of Serum Levels of Interleukin-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma
title_sort relevance of serum levels of interleukin-6 and syndecan-1 in patients with hepatocellular carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293347/
https://www.ncbi.nlm.nih.gov/pubmed/22396913
http://dx.doi.org/10.3797/scipharm.1110-07
work_keys_str_mv AT metwalyhebaa relevanceofserumlevelsofinterleukin6andsyndecan1inpatientswithhepatocellularcarcinoma
AT algayyarmohammedmh relevanceofserumlevelsofinterleukin6andsyndecan1inpatientswithhepatocellularcarcinoma
AT eletrebyshahira relevanceofserumlevelsofinterleukin6andsyndecan1inpatientswithhepatocellularcarcinoma
AT ebrahimmohameda relevanceofserumlevelsofinterleukin6andsyndecan1inpatientswithhepatocellularcarcinoma
AT elshishtawymamdouhm relevanceofserumlevelsofinterleukin6andsyndecan1inpatientswithhepatocellularcarcinoma