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Synthesis and Characterization of Organic Impurities in Bortezomib Anhydride Produced by a Convergent Technology

A profile of impurities in bortezomib anhydride, produced by a recently developed convergent technology, has been characterized. HPLC-MS analysis of the drug essence revealed three impurities: an epimer of bortezomib, resulting from partial racemization of l-phenylalanine’s stereogenic center during...

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Detalles Bibliográficos
Autores principales:	Ivanov, Andrey S., Shishkov, Sergey V., Zhalnina, Anna A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293353/ https://www.ncbi.nlm.nih.gov/pubmed/22396904 http://dx.doi.org/10.3797/scipharm.1109-02

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