Cargando…

Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG

Beclin 1 is a core component of the Class III Phosphatidylinositol 3-Kinase VPS34 complex. The coiled coil domain of Beclin 1 serves as an interaction platform for assembly of distinct Atg14L- and UVRAG-containing complexes to modulate VPS34 activity. Here we report the crystal structure of the coil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiaohua, He, Liqiang, Che, Ka Hing, Funderburk, Sarah F., Pan, Lifeng, Pan, Nina, Zhang, Mingjie, Yue, Zhenyu, Zhao, Yanxiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293417/ https://www.ncbi.nlm.nih.gov/pubmed/22314358 http://dx.doi.org/10.1038/ncomms1648

Ejemplares similares

Targeting the potent Beclin 1–UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking
por: Wu, Shuai, et al.
Publicado: (2018)

Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex
por: McKnight, Nicole C., et al.
Publicado: (2014)

Coiled-coil-mediated dimerization of Atg16 is required for binding to the PROPPIN Atg21
por: Bueno-Arribas, Miranda, et al.
Publicado: (2023)

A Set of Computationally Designed Orthogonal Antiparallel Homodimers that Expands the Synthetic Coiled-Coil Toolkit
por: Negron, Christopher, et al.
Publicado: (2014)

Coiled-coil heterodimer-based recruitment of an exonuclease to CRISPR/Cas for enhanced gene editing
por: Lainšček, Duško, et al.
Publicado: (2022)

Protein subunit interfaces: heterodimers versus homodimers
por: Zhanhua, Cui, et al.
Publicado: (2005)

PI(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the Beclin1 complex
por: He, Shanshan, et al.
Publicado: (2013)

Chibby forms a homodimer through a heptad repeat of leucine residues in its C-terminal coiled-coil motif
por: Mofunanya, Adaobi, et al.
Publicado: (2009)

The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing
por: Caillat, Christophe, et al.
Publicado: (2013)

VPS38/UVRAG and ATG14, the variant regulatory subunits of the ATG6/Beclin1-PI3K complexes, are crucial for the biogenesis of the yolk organelles and are transcriptionally regulated in the oocytes of the vector Rhodnius prolixus
por: Vieira, Priscila H., et al.
Publicado: (2021)

Coiled-coil heterodimers with increased stability for cellular regulation and sensing SARS-CoV-2 spike protein-mediated cell fusion
por: Plaper, Tjaša, et al.
Publicado: (2021)

Mapping Critical Residues in ATG11’s Coiled-Coil 2 Domain that Block Multiple Interactions and Disrupt Selective Autophagy
por: Meyer, Mitchell D., et al.
Publicado: (2022)

NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1–UVRAG Complex
por: Aikawa, Chihiro, et al.
Publicado: (2018)

Sibling rivalry among the ZBTB transcription factor family: homodimers versus heterodimers
por: Piepoli, Sofia, et al.
Publicado: (2022)

VEGF receptor heterodimers and homodimers are differentially expressed in neuronal and endothelial cell types
por: Sarkar, Joy, et al.
Publicado: (2022)

The coiled coil of in vitro assembled keratin filaments is a heterodimer of type I and II keratins: use of site-specific mutagenesis and recombinant protein expression
Publicado: (1990)

The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis
por: Rai, Shashank, et al.
Publicado: (2018)

ARCIMBOLDO on coiled coils
por: Caballero, Iracema, et al.
Publicado: (2018)

Beclin 1 and UVRAG Confer Protection from Radiation-Induced DNA Damage and Maintain Centrosome Stability in Colorectal Cancer Cells
por: Myung Park, Jae, et al.
Publicado: (2014)

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα
por: Fantauzzo, Katherine A., et al.
Publicado: (2016)

α/β coiled coils
por: Hartmann, Marcus D, et al.
Publicado: (2016)

Evolutionary Patterns in Coiled-Coils
por: Surkont, Jaroslaw, et al.
Publicado: (2015)

Coiled‐coils: The long and short of it
por: Truebestein, Linda, et al.
Publicado: (2016)

Curcumin Inhibited Podocyte Cell Apoptosis and Accelerated Cell Autophagy in Diabetic Nephropathy via Regulating Beclin1/UVRAG/Bcl2
por: Zhang, Pingping, et al.
Publicado: (2020)

The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins
por: Caillat, Christophe, et al.
Publicado: (2015)

Visualization of cardiac ventricular myosin heavy chain homodimers and heterodimers by monoclonal antibody epitope mapping
Publicado: (1987)

Solving coiled-coil protein structures
por: Dauter, Zbigniew
Publicado: (2015)

Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch
por: Lu, Jun, et al.
Publicado: (2006)

A splicing variant of EDS1 from Vitis vinifera forms homodimers but no heterodimers with PAD4
por: Voss, Martin, et al.
Publicado: (2023)

Magnetic measurements with the helmholtz coil and the potential coil
por: Steingroever, E, et al.
Publicado: (1997)

The Coiled Coils of Cohesin Are Conserved in Animals, but Not In Yeast
por: White, Glenn E., et al.
Publicado: (2009)

Magnetic fields of cylindrical coils and annular coils
por: Snow, Chester
Publicado: (1953)

Magnetic fields of cylindrical coils and annular coils
por: National Bureau of Standards. Washington, DC
Publicado: (1953)

Controlling the Assembly of Coiled–Coil Peptide Nanotubes
por: Thomas, Franziska, et al.
Publicado: (2015)

The Golgin Family of Coiled-Coil Tethering Proteins
por: Witkos, Tomasz M., et al.
Publicado: (2016)

Conformational Dynamics of Asparagine at Coiled-Coil Interfaces
por: Thomas, Franziska, et al.
Publicado: (2017)

Coiled-coil inspired functional inclusion bodies
por: Gil-Garcia, Marcos, et al.
Publicado: (2020)

The Structure and Topology of α-Helical Coiled Coils
por: Lupas, Andrei N., et al.
Publicado: (2017)

Biomaterials Made from Coiled-Coil Peptides
por: Conticello, Vincent, et al.
Publicado: (2017)

The N-Terminal Region of the Human Autophagy Protein ATG16L1 Contains a Domain That Folds into a Helical Structure Consistent with Formation of a Coiled-Coil
por: Parkhouse, Rhiannon, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_n24djcklg045aplpp0vm4uno28