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Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review

BACKGROUND: The role of human papillomavirus (HPV) in malignant and non-malignant genital diseases in women is well known and the corresponding epidemiological burden has been widely described. However, less is known about the role of HPV in anal, penile and head and neck cancer, and the burden of m...

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Autores principales: Hartwig, Susanne, Syrjänen, Stina, Dominiak-Felden, Géraldine, Brotons, Maria, Castellsagué, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293758/
https://www.ncbi.nlm.nih.gov/pubmed/22260541
http://dx.doi.org/10.1186/1471-2407-12-30
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author Hartwig, Susanne
Syrjänen, Stina
Dominiak-Felden, Géraldine
Brotons, Maria
Castellsagué, Xavier
author_facet Hartwig, Susanne
Syrjänen, Stina
Dominiak-Felden, Géraldine
Brotons, Maria
Castellsagué, Xavier
author_sort Hartwig, Susanne
collection PubMed
description BACKGROUND: The role of human papillomavirus (HPV) in malignant and non-malignant genital diseases in women is well known and the corresponding epidemiological burden has been widely described. However, less is known about the role of HPV in anal, penile and head and neck cancer, and the burden of malignant and non-malignant HPV-related diseases in men. The objective of this review is to estimate the epidemiological burden of HPV-related cancers and non-malignant diseases in men in Europe. METHODS: The annual number of new HPV-related cancers in men in Europe was estimated using Eurostat population data and applying cancer incidence rates published by the International Agency for Research on Cancer. The number of cancer cases attributable to HPV, and specifically to HPV16/18, was calculated based on the most relevant prevalence estimates. The annual number of new cases of genital warts was calculated from the most robust European studies; and latest HPV6/11 prevalence estimates were then applied. A literature review was also performed to retrieve exhaustive data on HPV infection at all anatomical sites under study, as well as incidence and prevalence of external genital warts, recurrent respiratory papillomatosis and HPV-related cancer trends in men in Europe. RESULTS: A total of 72, 694 new cancer cases at HPV-related anatomical sites were estimated to occur each year in men in Europe. 17,403 of these cancer cases could be attributable to HPV, with 15,497 of them specifically attributable to HPV16/18. In addition, between 286,682 and 325,722 new cases of genital warts attributable to HPV6/11were estimated to occur annually in men in Europe. CONCLUSIONS: The overall estimated epidemiological burden of HPV-related cancers and non-malignant diseases is high in men in Europe. Approximately 30% of all new cancer cases attributable to HPV16/18 that occur yearly in Europe were estimated to occur in men. As in women, the vast majority of HPV-positive cancer in men is related to HPV16/18, while almost all HPV-related non-malignant diseases are due to HPV6/11. A substantial number of these malignant and non-malignant diseases may potentially be prevented by quadrivalent HPV vaccination.
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spelling pubmed-32937582012-03-06 Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review Hartwig, Susanne Syrjänen, Stina Dominiak-Felden, Géraldine Brotons, Maria Castellsagué, Xavier BMC Cancer Research Article BACKGROUND: The role of human papillomavirus (HPV) in malignant and non-malignant genital diseases in women is well known and the corresponding epidemiological burden has been widely described. However, less is known about the role of HPV in anal, penile and head and neck cancer, and the burden of malignant and non-malignant HPV-related diseases in men. The objective of this review is to estimate the epidemiological burden of HPV-related cancers and non-malignant diseases in men in Europe. METHODS: The annual number of new HPV-related cancers in men in Europe was estimated using Eurostat population data and applying cancer incidence rates published by the International Agency for Research on Cancer. The number of cancer cases attributable to HPV, and specifically to HPV16/18, was calculated based on the most relevant prevalence estimates. The annual number of new cases of genital warts was calculated from the most robust European studies; and latest HPV6/11 prevalence estimates were then applied. A literature review was also performed to retrieve exhaustive data on HPV infection at all anatomical sites under study, as well as incidence and prevalence of external genital warts, recurrent respiratory papillomatosis and HPV-related cancer trends in men in Europe. RESULTS: A total of 72, 694 new cancer cases at HPV-related anatomical sites were estimated to occur each year in men in Europe. 17,403 of these cancer cases could be attributable to HPV, with 15,497 of them specifically attributable to HPV16/18. In addition, between 286,682 and 325,722 new cases of genital warts attributable to HPV6/11were estimated to occur annually in men in Europe. CONCLUSIONS: The overall estimated epidemiological burden of HPV-related cancers and non-malignant diseases is high in men in Europe. Approximately 30% of all new cancer cases attributable to HPV16/18 that occur yearly in Europe were estimated to occur in men. As in women, the vast majority of HPV-positive cancer in men is related to HPV16/18, while almost all HPV-related non-malignant diseases are due to HPV6/11. A substantial number of these malignant and non-malignant diseases may potentially be prevented by quadrivalent HPV vaccination. BioMed Central 2012-01-20 /pmc/articles/PMC3293758/ /pubmed/22260541 http://dx.doi.org/10.1186/1471-2407-12-30 Text en Copyright ©2011 Hartwig et al; licensee BioMed Central Ltd.. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hartwig, Susanne
Syrjänen, Stina
Dominiak-Felden, Géraldine
Brotons, Maria
Castellsagué, Xavier
Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review
title Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review
title_full Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review
title_fullStr Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review
title_full_unstemmed Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review
title_short Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review
title_sort estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in europe: a review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293758/
https://www.ncbi.nlm.nih.gov/pubmed/22260541
http://dx.doi.org/10.1186/1471-2407-12-30
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