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Synthesis of a Dual Functional Anti-MDR Tumor Agent PH II-7 with Elucidations of Anti-Tumor Effects and Mechanisms

Multidrug resistance mediated by P-glycoprotein in cancer cells has been a major issue that cripples the efficacy of chemotherapy agents. Aimed for improved efficacy against resistant cancer cells, we designed and synthesized 25 oxindole derivatives based on indirubin by structure-activity relations...

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Detalles Bibliográficos
Autores principales:	Su, Ye, Cheng, Xin, Tan, Yaohong, Hu, Yunhui, Zhou, Yuan, Liu, Juanni, Xu, Yuanfu, Xie, Yinliang, Wang, Caiyun, Gao, Yingdai, Wang, Jianxiang, Cheng, Tao, Yang, Chunzheng, Xiong, Dongsheng, Miao, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293869/ https://www.ncbi.nlm.nih.gov/pubmed/22403708 http://dx.doi.org/10.1371/journal.pone.0032782

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