Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

BACKGROUND: Genome-wide association studies in Japanese populations recently identified common variants in the KCNQ1 gene to be associated with type 2 diabetes. We examined the association of these variants within KCNQ1 with type 2 diabetes in a Dutch population, investigated their effects on insuli...

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Autores principales: van Vliet-Ostaptchouk, Jana V., van Haeften, Timon W., Landman, Gijs W. D., Reiling, Erwin, Kleefstra, Nanne, Bilo, Henk J. G., Klungel, Olaf H., de Boer, Anthonius, van Diemen, Cleo C., Wijmenga, Cisca, Boezen, H. Marike, Dekker, Jacqueline M., van 't Riet, Esther, Nijpels, Giel, Welschen, Laura M. C., Zavrelova, Hata, Bruin, Elinda J., Elbers, Clara C., Bauer, Florianne, Onland-Moret, N. Charlotte, van der Schouw, Yvonne T., Grobbee, Diederick E., Spijkerman, Annemieke M. W., van der A, Daphne L., Simonis-Bik, Annemarie M., Eekhoff, Elisabeth M. W., Diamant, Michaela, Kramer, Mark H. H., Boomsma, Dorret I., de Geus, Eco J., Willemsen, Gonneke, Slagboom, P. Eline, Hofker, Marten H., 't Hart, Leen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293880/
https://www.ncbi.nlm.nih.gov/pubmed/22403629
http://dx.doi.org/10.1371/journal.pone.0032148

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