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Genetics and functional genomics of type 2 diabetes mellitus
Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCG1α. These findings help un...
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC329413/ https://www.ncbi.nlm.nih.gov/pubmed/14659011 |
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author | Toye, Ayo Gauguier, Dominique |
author_facet | Toye, Ayo Gauguier, Dominique |
author_sort | Toye, Ayo |
collection | PubMed |
description | Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCG1α. These findings help unravel the complex pathogenesis and inheritance of polygenic type 2 diabetes mellitus. |
format | Text |
id | pubmed-329413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-3294132004-02-05 Genetics and functional genomics of type 2 diabetes mellitus Toye, Ayo Gauguier, Dominique Genome Biol Minireview Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCG1α. These findings help unravel the complex pathogenesis and inheritance of polygenic type 2 diabetes mellitus. BioMed Central 2003 2003-11-24 /pmc/articles/PMC329413/ /pubmed/14659011 Text en Copyright © 2003 BioMed Central Ltd |
spellingShingle | Minireview Toye, Ayo Gauguier, Dominique Genetics and functional genomics of type 2 diabetes mellitus |
title | Genetics and functional genomics of type 2 diabetes mellitus |
title_full | Genetics and functional genomics of type 2 diabetes mellitus |
title_fullStr | Genetics and functional genomics of type 2 diabetes mellitus |
title_full_unstemmed | Genetics and functional genomics of type 2 diabetes mellitus |
title_short | Genetics and functional genomics of type 2 diabetes mellitus |
title_sort | genetics and functional genomics of type 2 diabetes mellitus |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC329413/ https://www.ncbi.nlm.nih.gov/pubmed/14659011 |
work_keys_str_mv | AT toyeayo geneticsandfunctionalgenomicsoftype2diabetesmellitus AT gauguierdominique geneticsandfunctionalgenomicsoftype2diabetesmellitus |