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Genetics and functional genomics of type 2 diabetes mellitus

Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCG1α. These findings help un...

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Detalles Bibliográficos
Autores principales: Toye, Ayo, Gauguier, Dominique
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC329413/
https://www.ncbi.nlm.nih.gov/pubmed/14659011
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author Toye, Ayo
Gauguier, Dominique
author_facet Toye, Ayo
Gauguier, Dominique
author_sort Toye, Ayo
collection PubMed
description Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCG1α. These findings help unravel the complex pathogenesis and inheritance of polygenic type 2 diabetes mellitus.
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spelling pubmed-3294132004-02-05 Genetics and functional genomics of type 2 diabetes mellitus Toye, Ayo Gauguier, Dominique Genome Biol Minireview Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCG1α. These findings help unravel the complex pathogenesis and inheritance of polygenic type 2 diabetes mellitus. BioMed Central 2003 2003-11-24 /pmc/articles/PMC329413/ /pubmed/14659011 Text en Copyright © 2003 BioMed Central Ltd
spellingShingle Minireview
Toye, Ayo
Gauguier, Dominique
Genetics and functional genomics of type 2 diabetes mellitus
title Genetics and functional genomics of type 2 diabetes mellitus
title_full Genetics and functional genomics of type 2 diabetes mellitus
title_fullStr Genetics and functional genomics of type 2 diabetes mellitus
title_full_unstemmed Genetics and functional genomics of type 2 diabetes mellitus
title_short Genetics and functional genomics of type 2 diabetes mellitus
title_sort genetics and functional genomics of type 2 diabetes mellitus
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC329413/
https://www.ncbi.nlm.nih.gov/pubmed/14659011
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