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Multidrug-Resistant Acinetobacter baumannii

To understand the epidemiology of multidrug-resistant (MDR) Acinetobacter baumannii and define individual risk factors for MDR, we used epidemiologic methods, performed organism typing by pulsed-field gel electrophoresis (PFGE), and conducted a matched case-control retrospective study. We investigat...

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Autores principales: Abbo, Aharon, Navon-Venezia, Shiri, Hammer-Muntz, Orly, Krichali, Tami, Siegman-Igra, Yardena, Carmeli, Yehuda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294361/
https://www.ncbi.nlm.nih.gov/pubmed/15705318
http://dx.doi.org/10.3201/eid1101.040001
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author Abbo, Aharon
Navon-Venezia, Shiri
Hammer-Muntz, Orly
Krichali, Tami
Siegman-Igra, Yardena
Carmeli, Yehuda
author_facet Abbo, Aharon
Navon-Venezia, Shiri
Hammer-Muntz, Orly
Krichali, Tami
Siegman-Igra, Yardena
Carmeli, Yehuda
author_sort Abbo, Aharon
collection PubMed
description To understand the epidemiology of multidrug-resistant (MDR) Acinetobacter baumannii and define individual risk factors for MDR, we used epidemiologic methods, performed organism typing by pulsed-field gel electrophoresis (PFGE), and conducted a matched case-control retrospective study. We investigated 118 patients, on 27 wards, in whom MDR A. baumannii was isolated from clinical cultures. Each case-patient had a control without MDR A. baumannii and was matched for hospital length of stay, ward, and calendar time. The epidemiologic investigation found small clusters of up to 6 patients each with no common identified source. Ten different PFGE clones were found, of which 2 dominated. The PFGE pattern differed within temporospatial clusters, and antimicrobial drug susceptibility patterns varied within and between clones. Multivariate analysis identified the following significant risk factors: male sex, cardiovascular disease, having undergone mechanical ventilation, and having been treated with antimicrobial drugs (particularly metronidazole). Penicillins were protective. The complex epidemiology may explain why the emergence of MDR A. baumannii is difficult to control.
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spelling pubmed-32943612012-03-08 Multidrug-Resistant Acinetobacter baumannii Abbo, Aharon Navon-Venezia, Shiri Hammer-Muntz, Orly Krichali, Tami Siegman-Igra, Yardena Carmeli, Yehuda Emerg Infect Dis Research To understand the epidemiology of multidrug-resistant (MDR) Acinetobacter baumannii and define individual risk factors for MDR, we used epidemiologic methods, performed organism typing by pulsed-field gel electrophoresis (PFGE), and conducted a matched case-control retrospective study. We investigated 118 patients, on 27 wards, in whom MDR A. baumannii was isolated from clinical cultures. Each case-patient had a control without MDR A. baumannii and was matched for hospital length of stay, ward, and calendar time. The epidemiologic investigation found small clusters of up to 6 patients each with no common identified source. Ten different PFGE clones were found, of which 2 dominated. The PFGE pattern differed within temporospatial clusters, and antimicrobial drug susceptibility patterns varied within and between clones. Multivariate analysis identified the following significant risk factors: male sex, cardiovascular disease, having undergone mechanical ventilation, and having been treated with antimicrobial drugs (particularly metronidazole). Penicillins were protective. The complex epidemiology may explain why the emergence of MDR A. baumannii is difficult to control. Centers for Disease Control and Prevention 2005-01 /pmc/articles/PMC3294361/ /pubmed/15705318 http://dx.doi.org/10.3201/eid1101.040001 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Abbo, Aharon
Navon-Venezia, Shiri
Hammer-Muntz, Orly
Krichali, Tami
Siegman-Igra, Yardena
Carmeli, Yehuda
Multidrug-Resistant Acinetobacter baumannii
title Multidrug-Resistant Acinetobacter baumannii
title_full Multidrug-Resistant Acinetobacter baumannii
title_fullStr Multidrug-Resistant Acinetobacter baumannii
title_full_unstemmed Multidrug-Resistant Acinetobacter baumannii
title_short Multidrug-Resistant Acinetobacter baumannii
title_sort multidrug-resistant acinetobacter baumannii
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294361/
https://www.ncbi.nlm.nih.gov/pubmed/15705318
http://dx.doi.org/10.3201/eid1101.040001
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