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Multidrug-Resistant Acinetobacter baumannii
To understand the epidemiology of multidrug-resistant (MDR) Acinetobacter baumannii and define individual risk factors for MDR, we used epidemiologic methods, performed organism typing by pulsed-field gel electrophoresis (PFGE), and conducted a matched case-control retrospective study. We investigat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294361/ https://www.ncbi.nlm.nih.gov/pubmed/15705318 http://dx.doi.org/10.3201/eid1101.040001 |
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author | Abbo, Aharon Navon-Venezia, Shiri Hammer-Muntz, Orly Krichali, Tami Siegman-Igra, Yardena Carmeli, Yehuda |
author_facet | Abbo, Aharon Navon-Venezia, Shiri Hammer-Muntz, Orly Krichali, Tami Siegman-Igra, Yardena Carmeli, Yehuda |
author_sort | Abbo, Aharon |
collection | PubMed |
description | To understand the epidemiology of multidrug-resistant (MDR) Acinetobacter baumannii and define individual risk factors for MDR, we used epidemiologic methods, performed organism typing by pulsed-field gel electrophoresis (PFGE), and conducted a matched case-control retrospective study. We investigated 118 patients, on 27 wards, in whom MDR A. baumannii was isolated from clinical cultures. Each case-patient had a control without MDR A. baumannii and was matched for hospital length of stay, ward, and calendar time. The epidemiologic investigation found small clusters of up to 6 patients each with no common identified source. Ten different PFGE clones were found, of which 2 dominated. The PFGE pattern differed within temporospatial clusters, and antimicrobial drug susceptibility patterns varied within and between clones. Multivariate analysis identified the following significant risk factors: male sex, cardiovascular disease, having undergone mechanical ventilation, and having been treated with antimicrobial drugs (particularly metronidazole). Penicillins were protective. The complex epidemiology may explain why the emergence of MDR A. baumannii is difficult to control. |
format | Online Article Text |
id | pubmed-3294361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-32943612012-03-08 Multidrug-Resistant Acinetobacter baumannii Abbo, Aharon Navon-Venezia, Shiri Hammer-Muntz, Orly Krichali, Tami Siegman-Igra, Yardena Carmeli, Yehuda Emerg Infect Dis Research To understand the epidemiology of multidrug-resistant (MDR) Acinetobacter baumannii and define individual risk factors for MDR, we used epidemiologic methods, performed organism typing by pulsed-field gel electrophoresis (PFGE), and conducted a matched case-control retrospective study. We investigated 118 patients, on 27 wards, in whom MDR A. baumannii was isolated from clinical cultures. Each case-patient had a control without MDR A. baumannii and was matched for hospital length of stay, ward, and calendar time. The epidemiologic investigation found small clusters of up to 6 patients each with no common identified source. Ten different PFGE clones were found, of which 2 dominated. The PFGE pattern differed within temporospatial clusters, and antimicrobial drug susceptibility patterns varied within and between clones. Multivariate analysis identified the following significant risk factors: male sex, cardiovascular disease, having undergone mechanical ventilation, and having been treated with antimicrobial drugs (particularly metronidazole). Penicillins were protective. The complex epidemiology may explain why the emergence of MDR A. baumannii is difficult to control. Centers for Disease Control and Prevention 2005-01 /pmc/articles/PMC3294361/ /pubmed/15705318 http://dx.doi.org/10.3201/eid1101.040001 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Abbo, Aharon Navon-Venezia, Shiri Hammer-Muntz, Orly Krichali, Tami Siegman-Igra, Yardena Carmeli, Yehuda Multidrug-Resistant Acinetobacter baumannii |
title | Multidrug-Resistant Acinetobacter baumannii |
title_full | Multidrug-Resistant Acinetobacter baumannii |
title_fullStr | Multidrug-Resistant Acinetobacter baumannii |
title_full_unstemmed | Multidrug-Resistant Acinetobacter baumannii |
title_short | Multidrug-Resistant Acinetobacter baumannii |
title_sort | multidrug-resistant acinetobacter baumannii |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294361/ https://www.ncbi.nlm.nih.gov/pubmed/15705318 http://dx.doi.org/10.3201/eid1101.040001 |
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