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Genetic Background of Escherichia coli and Extended-spectrum β-Lactamase Type

To assess the implication of the genetic background of Escherichia coli strains in the emergence of extended-spectrum-β-lactamases (ESBL), 55 TEM-, 52 CTX-M-, and 22 SHV-type ESBL-producing clinical isolates involved in various extraintestinal infections or colonization were studied in terms of phyl...

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Autores principales: Branger, Catherine, Zamfir, Oana, Geoffroy, Sabine, Laurans, Geneviève, Arlet, Guillaume, Thien, Hoang Vu, Gouriou, Stéphanie, Picard, Bertrand, Denamur, Erick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294364/
https://www.ncbi.nlm.nih.gov/pubmed/15705323
http://dx.doi.org/10.3201/eid1101.040257
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author Branger, Catherine
Zamfir, Oana
Geoffroy, Sabine
Laurans, Geneviève
Arlet, Guillaume
Thien, Hoang Vu
Gouriou, Stéphanie
Picard, Bertrand
Denamur, Erick
author_facet Branger, Catherine
Zamfir, Oana
Geoffroy, Sabine
Laurans, Geneviève
Arlet, Guillaume
Thien, Hoang Vu
Gouriou, Stéphanie
Picard, Bertrand
Denamur, Erick
author_sort Branger, Catherine
collection PubMed
description To assess the implication of the genetic background of Escherichia coli strains in the emergence of extended-spectrum-β-lactamases (ESBL), 55 TEM-, 52 CTX-M-, and 22 SHV-type ESBL-producing clinical isolates involved in various extraintestinal infections or colonization were studied in terms of phylogenetic group, virulence factor (VF) content (pap, sfa/foc, hly, and aer genes), and fluoroquinolone resistance. A factorial analysis of correspondence showed that SHV type, and to a lesser extent TEM type, were preferentially observed in B2 phylogenetic group strains that exhibited numerous VFs but were fluoroquinolone-susceptible, whereas the newly emerged CTX-M type was associated with the D phylogenetic group strains that lacked VF but were fluoroquinolone-resistant. Thus, the emergence of ESBL-producing E. coli seems to be the result of complex interactions between the type of ESBL, genetic background of the strain, and selective pressures in ecologic niches.
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spelling pubmed-32943642012-03-08 Genetic Background of Escherichia coli and Extended-spectrum β-Lactamase Type Branger, Catherine Zamfir, Oana Geoffroy, Sabine Laurans, Geneviève Arlet, Guillaume Thien, Hoang Vu Gouriou, Stéphanie Picard, Bertrand Denamur, Erick Emerg Infect Dis Research To assess the implication of the genetic background of Escherichia coli strains in the emergence of extended-spectrum-β-lactamases (ESBL), 55 TEM-, 52 CTX-M-, and 22 SHV-type ESBL-producing clinical isolates involved in various extraintestinal infections or colonization were studied in terms of phylogenetic group, virulence factor (VF) content (pap, sfa/foc, hly, and aer genes), and fluoroquinolone resistance. A factorial analysis of correspondence showed that SHV type, and to a lesser extent TEM type, were preferentially observed in B2 phylogenetic group strains that exhibited numerous VFs but were fluoroquinolone-susceptible, whereas the newly emerged CTX-M type was associated with the D phylogenetic group strains that lacked VF but were fluoroquinolone-resistant. Thus, the emergence of ESBL-producing E. coli seems to be the result of complex interactions between the type of ESBL, genetic background of the strain, and selective pressures in ecologic niches. Centers for Disease Control and Prevention 2005-01 /pmc/articles/PMC3294364/ /pubmed/15705323 http://dx.doi.org/10.3201/eid1101.040257 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Branger, Catherine
Zamfir, Oana
Geoffroy, Sabine
Laurans, Geneviève
Arlet, Guillaume
Thien, Hoang Vu
Gouriou, Stéphanie
Picard, Bertrand
Denamur, Erick
Genetic Background of Escherichia coli and Extended-spectrum β-Lactamase Type
title Genetic Background of Escherichia coli and Extended-spectrum β-Lactamase Type
title_full Genetic Background of Escherichia coli and Extended-spectrum β-Lactamase Type
title_fullStr Genetic Background of Escherichia coli and Extended-spectrum β-Lactamase Type
title_full_unstemmed Genetic Background of Escherichia coli and Extended-spectrum β-Lactamase Type
title_short Genetic Background of Escherichia coli and Extended-spectrum β-Lactamase Type
title_sort genetic background of escherichia coli and extended-spectrum β-lactamase type
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294364/
https://www.ncbi.nlm.nih.gov/pubmed/15705323
http://dx.doi.org/10.3201/eid1101.040257
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