Cargando…
Measles Virus Strain Diversity, Nigeria and Democratic Republic of the Congo
We investigated the genetic diversity of measles virus (MV) in Nigeria (2004–2005) and the Democratic Republic of the Congo (DRC) (2002–2006). Genotype B3 strains circulating in Kinshasa, DRC, in 2002–2003 were fully replaced by genotype B2 in 2004 at the end of the second Congo war. In Nigeria (200...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294530/ https://www.ncbi.nlm.nih.gov/pubmed/21029530 http://dx.doi.org/10.3201/eid1611.100777 |
_version_ | 1782225502465949696 |
---|---|
author | Kremer, Jacques R. Nkwembe, Edith Oyefolu, Akeeb O. Bola Smit, Sheilagh B. Pukuta, Elisabeth Omilabu, Sunday A. Adu, Festus D. Tamfum, Jean-Jacques Muyembe Muller, Claude P. |
author_facet | Kremer, Jacques R. Nkwembe, Edith Oyefolu, Akeeb O. Bola Smit, Sheilagh B. Pukuta, Elisabeth Omilabu, Sunday A. Adu, Festus D. Tamfum, Jean-Jacques Muyembe Muller, Claude P. |
author_sort | Kremer, Jacques R. |
collection | PubMed |
description | We investigated the genetic diversity of measles virus (MV) in Nigeria (2004–2005) and the Democratic Republic of the Congo (DRC) (2002–2006). Genotype B3 strains circulating in Kinshasa, DRC, in 2002–2003 were fully replaced by genotype B2 in 2004 at the end of the second Congo war. In Nigeria (2004–2005), two genetic clusters of genotype B3, both of which were most closely related to 1 variant from 1998, were identified. Longitudinal analysis of MV strain diversity in Nigeria suggested that only a few of the previously described 1997–1998 variants had continued to circulate, but this finding was concomitant with a rapid restoration of genetic diversity, probably caused by low vaccination coverage and high birth rates. In contrast, the relatively low genetic diversity of MV in DRC and the genotype replacement in Kinshasa reflect a notable improvement in local measles control. |
format | Online Article Text |
id | pubmed-3294530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-32945302012-03-06 Measles Virus Strain Diversity, Nigeria and Democratic Republic of the Congo Kremer, Jacques R. Nkwembe, Edith Oyefolu, Akeeb O. Bola Smit, Sheilagh B. Pukuta, Elisabeth Omilabu, Sunday A. Adu, Festus D. Tamfum, Jean-Jacques Muyembe Muller, Claude P. Emerg Infect Dis Research We investigated the genetic diversity of measles virus (MV) in Nigeria (2004–2005) and the Democratic Republic of the Congo (DRC) (2002–2006). Genotype B3 strains circulating in Kinshasa, DRC, in 2002–2003 were fully replaced by genotype B2 in 2004 at the end of the second Congo war. In Nigeria (2004–2005), two genetic clusters of genotype B3, both of which were most closely related to 1 variant from 1998, were identified. Longitudinal analysis of MV strain diversity in Nigeria suggested that only a few of the previously described 1997–1998 variants had continued to circulate, but this finding was concomitant with a rapid restoration of genetic diversity, probably caused by low vaccination coverage and high birth rates. In contrast, the relatively low genetic diversity of MV in DRC and the genotype replacement in Kinshasa reflect a notable improvement in local measles control. Centers for Disease Control and Prevention 2010-11 /pmc/articles/PMC3294530/ /pubmed/21029530 http://dx.doi.org/10.3201/eid1611.100777 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Kremer, Jacques R. Nkwembe, Edith Oyefolu, Akeeb O. Bola Smit, Sheilagh B. Pukuta, Elisabeth Omilabu, Sunday A. Adu, Festus D. Tamfum, Jean-Jacques Muyembe Muller, Claude P. Measles Virus Strain Diversity, Nigeria and Democratic Republic of the Congo |
title | Measles Virus Strain Diversity, Nigeria and Democratic Republic of the Congo |
title_full | Measles Virus Strain Diversity, Nigeria and Democratic Republic of the Congo |
title_fullStr | Measles Virus Strain Diversity, Nigeria and Democratic Republic of the Congo |
title_full_unstemmed | Measles Virus Strain Diversity, Nigeria and Democratic Republic of the Congo |
title_short | Measles Virus Strain Diversity, Nigeria and Democratic Republic of the Congo |
title_sort | measles virus strain diversity, nigeria and democratic republic of the congo |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294530/ https://www.ncbi.nlm.nih.gov/pubmed/21029530 http://dx.doi.org/10.3201/eid1611.100777 |
work_keys_str_mv | AT kremerjacquesr measlesvirusstraindiversitynigeriaanddemocraticrepublicofthecongo AT nkwembeedith measlesvirusstraindiversitynigeriaanddemocraticrepublicofthecongo AT oyefoluakeebobola measlesvirusstraindiversitynigeriaanddemocraticrepublicofthecongo AT smitsheilaghb measlesvirusstraindiversitynigeriaanddemocraticrepublicofthecongo AT pukutaelisabeth measlesvirusstraindiversitynigeriaanddemocraticrepublicofthecongo AT omilabusundaya measlesvirusstraindiversitynigeriaanddemocraticrepublicofthecongo AT adufestusd measlesvirusstraindiversitynigeriaanddemocraticrepublicofthecongo AT tamfumjeanjacquesmuyembe measlesvirusstraindiversitynigeriaanddemocraticrepublicofthecongo AT mullerclaudep measlesvirusstraindiversitynigeriaanddemocraticrepublicofthecongo |