Cargando…

Lymph Node Biopsy Specimens and Diagnosis of Cat-scratch Disease

We report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (CSD). The specimens were examined by standard, cell culture, and molecular methods. Infectious agents were found in samples from 391 (49.7%) of 786 patients. The most commonly identi...

Descripción completa

Detalles Bibliográficos
Autores principales: Rolain, Jean-Marc, Lepidi, Hubert, Zanaret, Michel, Triglia, Jean-Michel, Michel, Gérard, Thomas, Pascal-Alexandre, Texereau, Michèle, Stein, Andreas, Romaru, Anette, Eb, François, Raoult, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294744/
https://www.ncbi.nlm.nih.gov/pubmed/17073081
http://dx.doi.org/10.3201/eid1209.060122
Descripción
Sumario:We report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (CSD). The specimens were examined by standard, cell culture, and molecular methods. Infectious agents were found in samples from 391 (49.7%) of 786 patients. The most commonly identified infectious agent was Bartonella henselae (245 patients, 31.2%), the agent of CSD. Mycobacteriosis was diagnosed in 54 patients (6.9%) by culture and retrospectively confirmed by using a specific real-time PCR assay. Neoplasm was diagnosed in 181 specimens suitable for histologic analysis (26.0%) from 47 patients. Moreover, 13 patients with confirmed Bartonella infections had concurrent mycobacteriosis (10 cases) or neoplasm (3 cases). A diagnosis of CSD does not eliminate a diagnosis of mycobacteriosis or neoplasm. Histologic analysis of lymph node biopsy specimens should be routinely performed because some patients might have a concurrent malignant disease or mycobacteriosis.