1,2-Bis[(3,6,9-trimethyl-3,12-ep­oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca­hydro­pyrano[4,3-j][1,2]benzodioxepin-4-yl)­oxy]ethane

The title compound, C(32)H(50)O(10), prepared from a mixture of α- and β-dihydro­artemisinin, has two β-arteether moieties linked via an –OCH(2)CH(2)O– bridge, so that the mol­ecule is symmetric about the bridge. Each asymmetric unit contains a β-arteether moiety and an –OCH(2) group, which is only...

Descripción completa

Detalles Bibliográficos
Autores principales: Jia, Liwei, Yue, Zhengyu, Lv, Dongying, Gao, Po
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295452/
https://www.ncbi.nlm.nih.gov/pubmed/22412563
http://dx.doi.org/10.1107/S1600536812005089
_version_ 1782225580964446208
author Jia, Liwei
Yue, Zhengyu
Lv, Dongying
Gao, Po
author_facet Jia, Liwei
Yue, Zhengyu
Lv, Dongying
Gao, Po
author_sort Jia, Liwei
collection PubMed
description The title compound, C(32)H(50)O(10), prepared from a mixture of α- and β-dihydro­artemisinin, has two β-arteether moieties linked via an –OCH(2)CH(2)O– bridge, so that the mol­ecule is symmetric about the bridge. Each asymmetric unit contains a β-arteether moiety and an –OCH(2) group, which is only one-half of the mol­ecule. The endo-peroxide bridges of the parent compounds have been retained in each half of the diol-bridged dimer. The rings exhibit chair and twist-boat conformations.
format Online
Article
Text
id pubmed-3295452
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-32954522012-03-12 1,2-Bis[(3,6,9-trimethyl-3,12-ep­oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca­hydro­pyrano[4,3-j][1,2]benzodioxepin-4-yl)­oxy]ethane Jia, Liwei Yue, Zhengyu Lv, Dongying Gao, Po Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(32)H(50)O(10), prepared from a mixture of α- and β-dihydro­artemisinin, has two β-arteether moieties linked via an –OCH(2)CH(2)O– bridge, so that the mol­ecule is symmetric about the bridge. Each asymmetric unit contains a β-arteether moiety and an –OCH(2) group, which is only one-half of the mol­ecule. The endo-peroxide bridges of the parent compounds have been retained in each half of the diol-bridged dimer. The rings exhibit chair and twist-boat conformations. International Union of Crystallography 2012-02-10 /pmc/articles/PMC3295452/ /pubmed/22412563 http://dx.doi.org/10.1107/S1600536812005089 Text en © Jia et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Jia, Liwei
Yue, Zhengyu
Lv, Dongying
Gao, Po
1,2-Bis[(3,6,9-trimethyl-3,12-ep­oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca­hydro­pyrano[4,3-j][1,2]benzodioxepin-4-yl)­oxy]ethane
title 1,2-Bis[(3,6,9-trimethyl-3,12-ep­oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca­hydro­pyrano[4,3-j][1,2]benzodioxepin-4-yl)­oxy]ethane
title_full 1,2-Bis[(3,6,9-trimethyl-3,12-ep­oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca­hydro­pyrano[4,3-j][1,2]benzodioxepin-4-yl)­oxy]ethane
title_fullStr 1,2-Bis[(3,6,9-trimethyl-3,12-ep­oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca­hydro­pyrano[4,3-j][1,2]benzodioxepin-4-yl)­oxy]ethane
title_full_unstemmed 1,2-Bis[(3,6,9-trimethyl-3,12-ep­oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca­hydro­pyrano[4,3-j][1,2]benzodioxepin-4-yl)­oxy]ethane
title_short 1,2-Bis[(3,6,9-trimethyl-3,12-ep­oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca­hydro­pyrano[4,3-j][1,2]benzodioxepin-4-yl)­oxy]ethane
title_sort 1,2-bis[(3,6,9-trimethyl-3,12-ep­oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca­hydro­pyrano[4,3-j][1,2]benzodioxepin-4-yl)­oxy]ethane
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295452/
https://www.ncbi.nlm.nih.gov/pubmed/22412563
http://dx.doi.org/10.1107/S1600536812005089
work_keys_str_mv AT jialiwei 12bis369trimethyl312epoxy3455a6788a9101212adodecahydropyrano43j12benzodioxepin4yloxyethane
AT yuezhengyu 12bis369trimethyl312epoxy3455a6788a9101212adodecahydropyrano43j12benzodioxepin4yloxyethane
AT lvdongying 12bis369trimethyl312epoxy3455a6788a9101212adodecahydropyrano43j12benzodioxepin4yloxyethane
AT gaopo 12bis369trimethyl312epoxy3455a6788a9101212adodecahydropyrano43j12benzodioxepin4yloxyethane

Ejemplares similares