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Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy
The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp). SP is an ideal choice for IPTp, however, as resistance of Plasmodium falciparum to SP increases, data are accumulating that SP may no longer provide benefit in areas of high-le...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295670/ https://www.ncbi.nlm.nih.gov/pubmed/22321288 http://dx.doi.org/10.1186/1475-2875-11-39 |
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author | Gutman, Julie Kachur, S Patrick Slutsker, Laurence Nzila, Alexis Mutabingwa, Theonest |
author_facet | Gutman, Julie Kachur, S Patrick Slutsker, Laurence Nzila, Alexis Mutabingwa, Theonest |
author_sort | Gutman, Julie |
collection | PubMed |
description | The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp). SP is an ideal choice for IPTp, however, as resistance of Plasmodium falciparum to SP increases, data are accumulating that SP may no longer provide benefit in areas of high-level resistance. Probenecid was initially used as an adjunctive therapy to increase the blood concentration of penicillin; it has since been used to augment concentrations of other drugs, including antifolates. The addition of probenecid has been shown to increase the treatment efficacy of SP against malaria, suggesting that the combination of probenecid plus SP may prolong the useful lifespan of SP as an effective agent for IPTp. Here, the literature on the pharmacokinetics, adverse reactions, interactions and available data on the use of these drugs in pregnancy is reviewed, and the possible utility of an SP-probenecid combination is discussed. This article concludes by calling for further research into this potentially useful combination. |
format | Online Article Text |
id | pubmed-3295670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32956702012-03-07 Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy Gutman, Julie Kachur, S Patrick Slutsker, Laurence Nzila, Alexis Mutabingwa, Theonest Malar J Review The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp). SP is an ideal choice for IPTp, however, as resistance of Plasmodium falciparum to SP increases, data are accumulating that SP may no longer provide benefit in areas of high-level resistance. Probenecid was initially used as an adjunctive therapy to increase the blood concentration of penicillin; it has since been used to augment concentrations of other drugs, including antifolates. The addition of probenecid has been shown to increase the treatment efficacy of SP against malaria, suggesting that the combination of probenecid plus SP may prolong the useful lifespan of SP as an effective agent for IPTp. Here, the literature on the pharmacokinetics, adverse reactions, interactions and available data on the use of these drugs in pregnancy is reviewed, and the possible utility of an SP-probenecid combination is discussed. This article concludes by calling for further research into this potentially useful combination. BioMed Central 2012-02-09 /pmc/articles/PMC3295670/ /pubmed/22321288 http://dx.doi.org/10.1186/1475-2875-11-39 Text en Copyright ©2012 Gutman et al; BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Gutman, Julie Kachur, S Patrick Slutsker, Laurence Nzila, Alexis Mutabingwa, Theonest Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy |
title | Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy |
title_full | Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy |
title_fullStr | Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy |
title_full_unstemmed | Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy |
title_short | Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy |
title_sort | combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295670/ https://www.ncbi.nlm.nih.gov/pubmed/22321288 http://dx.doi.org/10.1186/1475-2875-11-39 |
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