Cargando…

Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy

The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp). SP is an ideal choice for IPTp, however, as resistance of Plasmodium falciparum to SP increases, data are accumulating that SP may no longer provide benefit in areas of high-le...

Descripción completa

Detalles Bibliográficos
Autores principales: Gutman, Julie, Kachur, S Patrick, Slutsker, Laurence, Nzila, Alexis, Mutabingwa, Theonest
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295670/
https://www.ncbi.nlm.nih.gov/pubmed/22321288
http://dx.doi.org/10.1186/1475-2875-11-39
_version_ 1782225616213377024
author Gutman, Julie
Kachur, S Patrick
Slutsker, Laurence
Nzila, Alexis
Mutabingwa, Theonest
author_facet Gutman, Julie
Kachur, S Patrick
Slutsker, Laurence
Nzila, Alexis
Mutabingwa, Theonest
author_sort Gutman, Julie
collection PubMed
description The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp). SP is an ideal choice for IPTp, however, as resistance of Plasmodium falciparum to SP increases, data are accumulating that SP may no longer provide benefit in areas of high-level resistance. Probenecid was initially used as an adjunctive therapy to increase the blood concentration of penicillin; it has since been used to augment concentrations of other drugs, including antifolates. The addition of probenecid has been shown to increase the treatment efficacy of SP against malaria, suggesting that the combination of probenecid plus SP may prolong the useful lifespan of SP as an effective agent for IPTp. Here, the literature on the pharmacokinetics, adverse reactions, interactions and available data on the use of these drugs in pregnancy is reviewed, and the possible utility of an SP-probenecid combination is discussed. This article concludes by calling for further research into this potentially useful combination.
format Online
Article
Text
id pubmed-3295670
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-32956702012-03-07 Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy Gutman, Julie Kachur, S Patrick Slutsker, Laurence Nzila, Alexis Mutabingwa, Theonest Malar J Review The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp). SP is an ideal choice for IPTp, however, as resistance of Plasmodium falciparum to SP increases, data are accumulating that SP may no longer provide benefit in areas of high-level resistance. Probenecid was initially used as an adjunctive therapy to increase the blood concentration of penicillin; it has since been used to augment concentrations of other drugs, including antifolates. The addition of probenecid has been shown to increase the treatment efficacy of SP against malaria, suggesting that the combination of probenecid plus SP may prolong the useful lifespan of SP as an effective agent for IPTp. Here, the literature on the pharmacokinetics, adverse reactions, interactions and available data on the use of these drugs in pregnancy is reviewed, and the possible utility of an SP-probenecid combination is discussed. This article concludes by calling for further research into this potentially useful combination. BioMed Central 2012-02-09 /pmc/articles/PMC3295670/ /pubmed/22321288 http://dx.doi.org/10.1186/1475-2875-11-39 Text en Copyright ©2012 Gutman et al; BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gutman, Julie
Kachur, S Patrick
Slutsker, Laurence
Nzila, Alexis
Mutabingwa, Theonest
Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy
title Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy
title_full Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy
title_fullStr Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy
title_full_unstemmed Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy
title_short Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy
title_sort combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295670/
https://www.ncbi.nlm.nih.gov/pubmed/22321288
http://dx.doi.org/10.1186/1475-2875-11-39
work_keys_str_mv AT gutmanjulie combinationofprobenecidsulphadoxinepyrimethamineforintermittentpreventivetreatmentinpregnancy
AT kachurspatrick combinationofprobenecidsulphadoxinepyrimethamineforintermittentpreventivetreatmentinpregnancy
AT slutskerlaurence combinationofprobenecidsulphadoxinepyrimethamineforintermittentpreventivetreatmentinpregnancy
AT nzilaalexis combinationofprobenecidsulphadoxinepyrimethamineforintermittentpreventivetreatmentinpregnancy
AT mutabingwatheonest combinationofprobenecidsulphadoxinepyrimethamineforintermittentpreventivetreatmentinpregnancy