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Disease flare of ankylosing spondylitis presenting as reactive arthritis with seropositivity: a case report
INTRODUCTION: Concurrent rheumatoid factor seropositivity is occasionally detected in ankylosing spondylitis and often causes confusion in clinical routine. Overlap between various seronegative arthritides is a known but uncommon association. Differentiation of spondyloarthropathy from rheumatoid ar...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295684/ https://www.ncbi.nlm.nih.gov/pubmed/22333429 http://dx.doi.org/10.1186/1752-1947-6-60 |
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author | Manoj, EM Ragunathan, MK |
author_facet | Manoj, EM Ragunathan, MK |
author_sort | Manoj, EM |
collection | PubMed |
description | INTRODUCTION: Concurrent rheumatoid factor seropositivity is occasionally detected in ankylosing spondylitis and often causes confusion in clinical routine. Overlap between various seronegative arthritides is a known but uncommon association. Differentiation of spondyloarthropathy from rheumatoid arthritis is important, since the natural history, complications, treatments and prognosis of the two diseases differ significantly. CASE PRESENTATION: Here, we report the case of a 47-year-old Sri Lankan man who had a long history of intermittent joint pains worsening following a recent episode of self-resolving non-bloody diarrhea. Subsequently, he developed a skin rash suggestive of keratoderma blenorrhagica and circinate balanitis. He had classical radiological evidence of ankylosing spondylosis (previously undiagnosed) associated with human leukocyte antigen B27 antigen, but was positive for rheumatoid factor. CONCLUSIONS: A disease flare of ankylosing spondylitis prompted by a minor diarrheal illness showing well documented features of reactive arthritis is remarkable. The prognostic implications of seropositivity in spondyloarthritis are discussed. |
format | Online Article Text |
id | pubmed-3295684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32956842012-03-07 Disease flare of ankylosing spondylitis presenting as reactive arthritis with seropositivity: a case report Manoj, EM Ragunathan, MK J Med Case Reports Case Report INTRODUCTION: Concurrent rheumatoid factor seropositivity is occasionally detected in ankylosing spondylitis and often causes confusion in clinical routine. Overlap between various seronegative arthritides is a known but uncommon association. Differentiation of spondyloarthropathy from rheumatoid arthritis is important, since the natural history, complications, treatments and prognosis of the two diseases differ significantly. CASE PRESENTATION: Here, we report the case of a 47-year-old Sri Lankan man who had a long history of intermittent joint pains worsening following a recent episode of self-resolving non-bloody diarrhea. Subsequently, he developed a skin rash suggestive of keratoderma blenorrhagica and circinate balanitis. He had classical radiological evidence of ankylosing spondylosis (previously undiagnosed) associated with human leukocyte antigen B27 antigen, but was positive for rheumatoid factor. CONCLUSIONS: A disease flare of ankylosing spondylitis prompted by a minor diarrheal illness showing well documented features of reactive arthritis is remarkable. The prognostic implications of seropositivity in spondyloarthritis are discussed. BioMed Central 2012-02-14 /pmc/articles/PMC3295684/ /pubmed/22333429 http://dx.doi.org/10.1186/1752-1947-6-60 Text en Copyright ©2012 Manoj and Ragunathan; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Manoj, EM Ragunathan, MK Disease flare of ankylosing spondylitis presenting as reactive arthritis with seropositivity: a case report |
title | Disease flare of ankylosing spondylitis presenting as reactive arthritis with seropositivity: a case report |
title_full | Disease flare of ankylosing spondylitis presenting as reactive arthritis with seropositivity: a case report |
title_fullStr | Disease flare of ankylosing spondylitis presenting as reactive arthritis with seropositivity: a case report |
title_full_unstemmed | Disease flare of ankylosing spondylitis presenting as reactive arthritis with seropositivity: a case report |
title_short | Disease flare of ankylosing spondylitis presenting as reactive arthritis with seropositivity: a case report |
title_sort | disease flare of ankylosing spondylitis presenting as reactive arthritis with seropositivity: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295684/ https://www.ncbi.nlm.nih.gov/pubmed/22333429 http://dx.doi.org/10.1186/1752-1947-6-60 |
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