Cargando…

The Tempered Polymerization of Human Neuroserpin

Neuroserpin, a member of the serpin protein superfamily, is an inhibitor of proteolytic activity that is involved in pathologies such as ischemia, Alzheimer's disease, and Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB). The latter belongs to a class of conformational diseases...

Descripción completa

Detalles Bibliográficos
Autores principales:	Noto, Rosina, Santangelo, Maria Grazia, Ricagno, Stefano, Mangione, Maria Rosalia, Levantino, Matteo, Pezzullo, Margherita, Martorana, Vincenzo, Cupane, Antonio, Bolognesi, Martino, Manno, Mauro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295756/ https://www.ncbi.nlm.nih.gov/pubmed/22412873 http://dx.doi.org/10.1371/journal.pone.0032444

Ejemplares similares

Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics
por: Noto, Rosina, et al.
Publicado: (2015)

Embelin binds to human neuroserpin and impairs its polymerisation
por: Saga, Giorgia, et al.
Publicado: (2016)

The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop
por: Noto, Rosina, et al.
Publicado: (2015)

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors
por: Visentin, Cristina, et al.
Publicado: (2020)

Neuroserpin: structure, function, physiology and pathology
por: D’Acunto, Emanuela, et al.
Publicado: (2021)

The Possible Role of the Type I Chaperonins in Human Insulin Self-Association
por: Pizzo, Federica, et al.
Publicado: (2022)

Interactions between N‐linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum
por: Moriconi, Claudia, et al.
Publicado: (2015)

Glycosylation Tunes Neuroserpin Physiological and Pathological Properties
por: Visentin, Cristina, et al.
Publicado: (2020)

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB
por: Miranda, Elena, et al.
Publicado: (2008)

Cholesterol impairment contributes to neuroserpin aggregation
por: Giampietro, Costanza, et al.
Publicado: (2017)

Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis
por: de Rosa, Matteo, et al.
Publicado: (2015)

Scaling Concepts in Serpin Polymer Physics
por: Raccosta, Samuele, et al.
Publicado: (2021)

The Neuroprotective Role of Neuroserpin in Ischemic and Hemorrhagic Stroke
por: Ding, Shanshan, et al.
Publicado: (2021)

Strand 1A variant in neuroserpin shows increased aggregation and no loss of inhibition: implication in ameliorating polymerization to retain activity
por: Ansari, Shoyab, et al.
Publicado: (2022)

Neuroserpin Inclusion Bodies in a FENIB Yeast Model
por: Vapore, Valentina, et al.
Publicado: (2021)

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation
por: West, Jennifer, et al.
Publicado: (2021)

Observing heme doming in myoglobin with femtosecond X-ray absorption spectroscopya)
por: Levantino, M., et al.
Publicado: (2015)

Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser
por: Levantino, Matteo, et al.
Publicado: (2015)

Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system★
por: Ma, Jiao, et al.
Publicado: (2012)

Chitosan-myristate nanogel as an artificial chaperone protects neuroserpin from misfolding
por: Nazem, Habib, et al.
Publicado: (2016)

Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB
por: Guadagno, Noemi A., et al.
Publicado: (2017)

Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin
por: Gupta, Vivek, et al.
Publicado: (2017)

Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke
por: Rodríguez-González, Raquel, et al.
Publicado: (2011)

Neuroprotective Effect of Neuroserpin in Oxygen-Glucose Deprivation- and Reoxygenation-Treated Rat Astrocytes In Vitro
por: Wang, Liang, et al.
Publicado: (2015)

Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system
por: Lee, Tet Woo, et al.
Publicado: (2015)

Neuroprotective effect of neuroserpin in non-tPA-induced intracerebral hemorrhage mouse models
por: Li, Wei, et al.
Publicado: (2017)

G392E neuroserpin causing the dementia FENIB is secreted from cells but is not synaptotoxic
por: Ingwersen, Thies, et al.
Publicado: (2021)

Protein–Protein Interactions in Dilute to Concentrated Solutions: α-Chymotrypsinogen in Acidic Conditions
por: Blanco, Marco A., et al.
Publicado: (2014)

Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study
por: Cole, John W, et al.
Publicado: (2007)

Deficiency in Serine Protease Inhibitor Neuroserpin Exacerbates Ischemic Brain Injury by Increased Postischemic Inflammation
por: Gelderblom, Mathias, et al.
Publicado: (2013)

Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB
por: Roussel, Benoit D., et al.
Publicado: (2013)

The serine protease inhibitor neuroserpin is required for normal synaptic plasticity and regulates learning and social behavior
por: Reumann, Rebecca, et al.
Publicado: (2017)

Neuroserpin restores autophagy and promotes functional recovery after acute spinal cord injury in rats
por: Li, Zheng, et al.
Publicado: (2018)

Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing
por: Adorjan, Istvan, et al.
Publicado: (2019)

Retina Is Protected by Neuroserpin from Ischemic/Reperfusion-Induced Injury Independent of Tissue-Type Plasminogen Activator
por: Gu, R. P., et al.
Publicado: (2015)

Neuroserpin Differentiates Between Forms of Tissue Type Plasminogen Activator via pH Dependent Deacylation
por: Carlson, Karen-Sue B., et al.
Publicado: (2016)

Neuroserpin, a crucial regulator for axogenesis, synaptic modelling and cell–cell interactions in the pathophysiology of neurological disease
por: Godinez, Angela, et al.
Publicado: (2022)

Wild Type Beta-2 Microglobulin and DE Loop Mutants Display a Common Fibrillar Architecture
por: Natalello, Antonino, et al.
Publicado: (2015)

The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure
por: Raimondi, Sara, et al.
Publicado: (2011)

A covalent homodimer probing early oligomers along amyloid aggregation
por: Halabelian, Levon, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_046hh1q2bscaljarov9hb0a1ue