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The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways

AIMS/HYPOTHESIS: Pancreatic islet microendothelium exhibits unique features in interdependent relationship with beta cells. Gastrointestinal products of the ghrelin gene, acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin (Ob), and the incretin, glucagon-like peptide-1 (GLP-1), prevent ap...

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Detalles Bibliográficos
Autores principales:	Favaro, E., Granata, R., Miceli, I., Baragli, A., Settanni, F., Cavallo Perin, P., Ghigo, E., Camussi, G., Zanone, M. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296004/ https://www.ncbi.nlm.nih.gov/pubmed/22231124 http://dx.doi.org/10.1007/s00125-011-2423-y

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