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Antimicrobials for Preterm Birth Prevention: An Overview

Objective. Preterm birth (PTB) remains a major cause of neonatal morbidity and mortality. The association between PTB and infection is clear. The purpose of this report is to present a focused review of information on the use of antibiotics to prevent PTB. Methods. We performed a search of the PubMe...

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Detalles Bibliográficos
Autores principales: Subramaniam, Akila, Abramovici, Adi, Andrews, William W., Tita, Alan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296158/
https://www.ncbi.nlm.nih.gov/pubmed/22505797
http://dx.doi.org/10.1155/2012/157159
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author Subramaniam, Akila
Abramovici, Adi
Andrews, William W.
Tita, Alan T.
author_facet Subramaniam, Akila
Abramovici, Adi
Andrews, William W.
Tita, Alan T.
author_sort Subramaniam, Akila
collection PubMed
description Objective. Preterm birth (PTB) remains a major cause of neonatal morbidity and mortality. The association between PTB and infection is clear. The purpose of this report is to present a focused review of information on the use of antibiotics to prevent PTB. Methods. We performed a search of the PubMed database restricted to clinical trials or meta-analyses published in English from 1990 through May 2011 using keywords “antibiotics or antimicrobials” and “preterm.” Results. The search yielded 67 abstracts for review. We selected 31 clinical trials (n = 26) or meta-analysis (n = 5) for further full-text review. Discussion of each eligible clinical trial, its specific inclusion criteria, antibiotic regimen used, and study results are presented. Overall, trials evaluating antibiotic treatment to prevent preterm birth have yielded mixed results regarding any benefit. Conclusion. Routine antibiotic prophylaxis is not recommended for prevention of preterm birth.
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spelling pubmed-32961582012-04-13 Antimicrobials for Preterm Birth Prevention: An Overview Subramaniam, Akila Abramovici, Adi Andrews, William W. Tita, Alan T. Infect Dis Obstet Gynecol Review Article Objective. Preterm birth (PTB) remains a major cause of neonatal morbidity and mortality. The association between PTB and infection is clear. The purpose of this report is to present a focused review of information on the use of antibiotics to prevent PTB. Methods. We performed a search of the PubMed database restricted to clinical trials or meta-analyses published in English from 1990 through May 2011 using keywords “antibiotics or antimicrobials” and “preterm.” Results. The search yielded 67 abstracts for review. We selected 31 clinical trials (n = 26) or meta-analysis (n = 5) for further full-text review. Discussion of each eligible clinical trial, its specific inclusion criteria, antibiotic regimen used, and study results are presented. Overall, trials evaluating antibiotic treatment to prevent preterm birth have yielded mixed results regarding any benefit. Conclusion. Routine antibiotic prophylaxis is not recommended for prevention of preterm birth. Hindawi Publishing Corporation 2012 2012-02-25 /pmc/articles/PMC3296158/ /pubmed/22505797 http://dx.doi.org/10.1155/2012/157159 Text en Copyright © 2012 Akila Subramaniam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Subramaniam, Akila
Abramovici, Adi
Andrews, William W.
Tita, Alan T.
Antimicrobials for Preterm Birth Prevention: An Overview
title Antimicrobials for Preterm Birth Prevention: An Overview
title_full Antimicrobials for Preterm Birth Prevention: An Overview
title_fullStr Antimicrobials for Preterm Birth Prevention: An Overview
title_full_unstemmed Antimicrobials for Preterm Birth Prevention: An Overview
title_short Antimicrobials for Preterm Birth Prevention: An Overview
title_sort antimicrobials for preterm birth prevention: an overview
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296158/
https://www.ncbi.nlm.nih.gov/pubmed/22505797
http://dx.doi.org/10.1155/2012/157159
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