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Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of co...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296207/ https://www.ncbi.nlm.nih.gov/pubmed/22505926 http://dx.doi.org/10.1155/2012/306879 |
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author | Kim, Yong-Nyun Koo, Kyung Hee Sung, Jee Young Yun, Un-Jung Kim, Hyeryeong |
author_facet | Kim, Yong-Nyun Koo, Kyung Hee Sung, Jee Young Yun, Un-Jung Kim, Hyeryeong |
author_sort | Kim, Yong-Nyun |
collection | PubMed |
description | Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of contact with the extracellular matrix or neighboring cells. Cancer cells acquire anoikis resistance to survive after detachment from the primary sites and travel through the circulatory and lymphatic systems to disseminate throughout the body. Because recent technological advances enable us to detect rare circulating tumor cells, which are anoikis resistant, currently, anoikis resistance becomes a hot topic in cancer research. Detailed molecular and functional analyses of anoikis resistant cells may provide insight into the biology of cancer metastasis and identify novel therapeutic targets for prevention of cancer dissemination. This paper comprehensively describes recent investigations of the molecular and cellular mechanisms underlying anoikis and anoikis resistance in relation to intrinsic and extrinsic death signaling, epithelial-mesenchymal transition, growth factor receptors, energy metabolism, reactive oxygen species, membrane microdomains, and lipid rafts. |
format | Online Article Text |
id | pubmed-3296207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32962072012-04-13 Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis Kim, Yong-Nyun Koo, Kyung Hee Sung, Jee Young Yun, Un-Jung Kim, Hyeryeong Int J Cell Biol Review Article Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of contact with the extracellular matrix or neighboring cells. Cancer cells acquire anoikis resistance to survive after detachment from the primary sites and travel through the circulatory and lymphatic systems to disseminate throughout the body. Because recent technological advances enable us to detect rare circulating tumor cells, which are anoikis resistant, currently, anoikis resistance becomes a hot topic in cancer research. Detailed molecular and functional analyses of anoikis resistant cells may provide insight into the biology of cancer metastasis and identify novel therapeutic targets for prevention of cancer dissemination. This paper comprehensively describes recent investigations of the molecular and cellular mechanisms underlying anoikis and anoikis resistance in relation to intrinsic and extrinsic death signaling, epithelial-mesenchymal transition, growth factor receptors, energy metabolism, reactive oxygen species, membrane microdomains, and lipid rafts. Hindawi Publishing Corporation 2012 2012-02-23 /pmc/articles/PMC3296207/ /pubmed/22505926 http://dx.doi.org/10.1155/2012/306879 Text en Copyright © 2012 Yong-Nyun Kim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kim, Yong-Nyun Koo, Kyung Hee Sung, Jee Young Yun, Un-Jung Kim, Hyeryeong Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis |
title | Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis |
title_full | Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis |
title_fullStr | Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis |
title_full_unstemmed | Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis |
title_short | Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis |
title_sort | anoikis resistance: an essential prerequisite for tumor metastasis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296207/ https://www.ncbi.nlm.nih.gov/pubmed/22505926 http://dx.doi.org/10.1155/2012/306879 |
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