Cargando…

Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis

Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of co...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Yong-Nyun, Koo, Kyung Hee, Sung, Jee Young, Yun, Un-Jung, Kim, Hyeryeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296207/
https://www.ncbi.nlm.nih.gov/pubmed/22505926
http://dx.doi.org/10.1155/2012/306879
_version_ 1782225691287224320
author Kim, Yong-Nyun
Koo, Kyung Hee
Sung, Jee Young
Yun, Un-Jung
Kim, Hyeryeong
author_facet Kim, Yong-Nyun
Koo, Kyung Hee
Sung, Jee Young
Yun, Un-Jung
Kim, Hyeryeong
author_sort Kim, Yong-Nyun
collection PubMed
description Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of contact with the extracellular matrix or neighboring cells. Cancer cells acquire anoikis resistance to survive after detachment from the primary sites and travel through the circulatory and lymphatic systems to disseminate throughout the body. Because recent technological advances enable us to detect rare circulating tumor cells, which are anoikis resistant, currently, anoikis resistance becomes a hot topic in cancer research. Detailed molecular and functional analyses of anoikis resistant cells may provide insight into the biology of cancer metastasis and identify novel therapeutic targets for prevention of cancer dissemination. This paper comprehensively describes recent investigations of the molecular and cellular mechanisms underlying anoikis and anoikis resistance in relation to intrinsic and extrinsic death signaling, epithelial-mesenchymal transition, growth factor receptors, energy metabolism, reactive oxygen species, membrane microdomains, and lipid rafts.
format Online
Article
Text
id pubmed-3296207
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-32962072012-04-13 Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis Kim, Yong-Nyun Koo, Kyung Hee Sung, Jee Young Yun, Un-Jung Kim, Hyeryeong Int J Cell Biol Review Article Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of contact with the extracellular matrix or neighboring cells. Cancer cells acquire anoikis resistance to survive after detachment from the primary sites and travel through the circulatory and lymphatic systems to disseminate throughout the body. Because recent technological advances enable us to detect rare circulating tumor cells, which are anoikis resistant, currently, anoikis resistance becomes a hot topic in cancer research. Detailed molecular and functional analyses of anoikis resistant cells may provide insight into the biology of cancer metastasis and identify novel therapeutic targets for prevention of cancer dissemination. This paper comprehensively describes recent investigations of the molecular and cellular mechanisms underlying anoikis and anoikis resistance in relation to intrinsic and extrinsic death signaling, epithelial-mesenchymal transition, growth factor receptors, energy metabolism, reactive oxygen species, membrane microdomains, and lipid rafts. Hindawi Publishing Corporation 2012 2012-02-23 /pmc/articles/PMC3296207/ /pubmed/22505926 http://dx.doi.org/10.1155/2012/306879 Text en Copyright © 2012 Yong-Nyun Kim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Yong-Nyun
Koo, Kyung Hee
Sung, Jee Young
Yun, Un-Jung
Kim, Hyeryeong
Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
title Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
title_full Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
title_fullStr Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
title_full_unstemmed Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
title_short Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
title_sort anoikis resistance: an essential prerequisite for tumor metastasis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296207/
https://www.ncbi.nlm.nih.gov/pubmed/22505926
http://dx.doi.org/10.1155/2012/306879
work_keys_str_mv AT kimyongnyun anoikisresistanceanessentialprerequisitefortumormetastasis
AT kookyunghee anoikisresistanceanessentialprerequisitefortumormetastasis
AT sungjeeyoung anoikisresistanceanessentialprerequisitefortumormetastasis
AT yununjung anoikisresistanceanessentialprerequisitefortumormetastasis
AT kimhyeryeong anoikisresistanceanessentialprerequisitefortumormetastasis