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The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow
Despite diagnostic advances, breast cancer remains the most prevalent cancer among women in the United States. The armamentarium of treatment options for metastatic disease is limited and mostly ineffective with regards to eradicating cancer. However, there have been novel findings in the recent lit...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296216/ https://www.ncbi.nlm.nih.gov/pubmed/22482060 http://dx.doi.org/10.1155/2012/721659 |
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author | Reddy, Bobby Y. Lim, Philip K. Silverio, Kimberly Patel, Shyam A. Won, Brian Wong Rameshwar, Pranela |
author_facet | Reddy, Bobby Y. Lim, Philip K. Silverio, Kimberly Patel, Shyam A. Won, Brian Wong Rameshwar, Pranela |
author_sort | Reddy, Bobby Y. |
collection | PubMed |
description | Despite diagnostic advances, breast cancer remains the most prevalent cancer among women in the United States. The armamentarium of treatment options for metastatic disease is limited and mostly ineffective with regards to eradicating cancer. However, there have been novel findings in the recent literature that substantiate the function of the microenvironment in breast cancer progression and the support of metastasis to tertiary sites such as bone marrow. The uncovered significance of the microenvironment in the pathophysiology of breast cancer metastasis has served to challenge previously widespread theories and introduce new perspectives for the future research to eradicate breast cancer. This paper delineates the current understanding of the molecular mechanisms involved in the interactions between breast cancer cells and the microenvironment in progression, metastasis, and dormancy. The information, in addition to other mechanisms described in bone marrow, is discussed in the paper. |
format | Online Article Text |
id | pubmed-3296216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32962162012-04-05 The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow Reddy, Bobby Y. Lim, Philip K. Silverio, Kimberly Patel, Shyam A. Won, Brian Wong Rameshwar, Pranela Int J Breast Cancer Review Article Despite diagnostic advances, breast cancer remains the most prevalent cancer among women in the United States. The armamentarium of treatment options for metastatic disease is limited and mostly ineffective with regards to eradicating cancer. However, there have been novel findings in the recent literature that substantiate the function of the microenvironment in breast cancer progression and the support of metastasis to tertiary sites such as bone marrow. The uncovered significance of the microenvironment in the pathophysiology of breast cancer metastasis has served to challenge previously widespread theories and introduce new perspectives for the future research to eradicate breast cancer. This paper delineates the current understanding of the molecular mechanisms involved in the interactions between breast cancer cells and the microenvironment in progression, metastasis, and dormancy. The information, in addition to other mechanisms described in bone marrow, is discussed in the paper. Hindawi Publishing Corporation 2012 2012-02-06 /pmc/articles/PMC3296216/ /pubmed/22482060 http://dx.doi.org/10.1155/2012/721659 Text en Copyright © 2012 Bobby Y. Reddy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Reddy, Bobby Y. Lim, Philip K. Silverio, Kimberly Patel, Shyam A. Won, Brian Wong Rameshwar, Pranela The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow |
title | The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow |
title_full | The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow |
title_fullStr | The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow |
title_full_unstemmed | The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow |
title_short | The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow |
title_sort | microenvironmental effect in the progression, metastasis, and dormancy of breast cancer: a model system within bone marrow |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296216/ https://www.ncbi.nlm.nih.gov/pubmed/22482060 http://dx.doi.org/10.1155/2012/721659 |
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