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Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension
Endothelial dysfunction is one of the main characteristics of chronic hypertension and it is characterized by impaired nitric oxide (NO) bioactivity determined by increased levels of reactive oxygen species. Endothelial function is usually evaluated by measuring the vasodilation induced by the local...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296220/ https://www.ncbi.nlm.nih.gov/pubmed/22518280 http://dx.doi.org/10.1155/2012/187526 |
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author | Neves, Mario Fritsch Kasal, Daniel Arthur B. Cunha, Ana Rosa Medeiros, Fernanda |
author_facet | Neves, Mario Fritsch Kasal, Daniel Arthur B. Cunha, Ana Rosa Medeiros, Fernanda |
author_sort | Neves, Mario Fritsch |
collection | PubMed |
description | Endothelial dysfunction is one of the main characteristics of chronic hypertension and it is characterized by impaired nitric oxide (NO) bioactivity determined by increased levels of reactive oxygen species. Endothelial function is usually evaluated by measuring the vasodilation induced by the local NO production stimulated by external mechanical or pharmacological agent. These vascular reactivity tests may be carried out in different models of experimental hypertension such as NO-deficient rats, spontaneously hypertensive rats, salt-sensitive rats, and many others. Wire myograph and pressurized myograph are the principal methods used for vascular studies. Usually, increasing concentrations of the vasodilator acetylcholine are added in cumulative manner to perform endothelium-dependent concentration-response curves. Analysis of vascular mechanics is relevant to identify arterial stiffness. Both endothelial dysfunction and vascular stiffness have been shown to be associated with increased cardiovascular risk. |
format | Online Article Text |
id | pubmed-3296220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32962202012-04-19 Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension Neves, Mario Fritsch Kasal, Daniel Arthur B. Cunha, Ana Rosa Medeiros, Fernanda Int J Hypertens Review Article Endothelial dysfunction is one of the main characteristics of chronic hypertension and it is characterized by impaired nitric oxide (NO) bioactivity determined by increased levels of reactive oxygen species. Endothelial function is usually evaluated by measuring the vasodilation induced by the local NO production stimulated by external mechanical or pharmacological agent. These vascular reactivity tests may be carried out in different models of experimental hypertension such as NO-deficient rats, spontaneously hypertensive rats, salt-sensitive rats, and many others. Wire myograph and pressurized myograph are the principal methods used for vascular studies. Usually, increasing concentrations of the vasodilator acetylcholine are added in cumulative manner to perform endothelium-dependent concentration-response curves. Analysis of vascular mechanics is relevant to identify arterial stiffness. Both endothelial dysfunction and vascular stiffness have been shown to be associated with increased cardiovascular risk. Hindawi Publishing Corporation 2012 2012-02-14 /pmc/articles/PMC3296220/ /pubmed/22518280 http://dx.doi.org/10.1155/2012/187526 Text en Copyright © 2012 Mario Fritsch Neves et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Neves, Mario Fritsch Kasal, Daniel Arthur B. Cunha, Ana Rosa Medeiros, Fernanda Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension |
title | Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension |
title_full | Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension |
title_fullStr | Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension |
title_full_unstemmed | Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension |
title_short | Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension |
title_sort | vascular dysfunction as target organ damage in animal models of hypertension |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296220/ https://www.ncbi.nlm.nih.gov/pubmed/22518280 http://dx.doi.org/10.1155/2012/187526 |
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