Potential of Novel EPO Derivatives in Limb Ischemia

Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and...

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Detalles Bibliográficos
Autores principales: Joshi, Dhiraj, Tsui, Janice, Yu, Rebekah, Shiwen, Xu, Selvakumar, Sadasivam, Abraham, David J., Baker, Daryll M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296231/
https://www.ncbi.nlm.nih.gov/pubmed/22462027
http://dx.doi.org/10.1155/2012/213785
Descripción
Sumario:Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and safety. This paper summarizes the development in EPO derivatives with emphasis on their potential use in critical limb ischaemia.

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