Potential of Novel EPO Derivatives in Limb Ischemia

Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and...

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Detalles Bibliográficos
Autores principales: Joshi, Dhiraj, Tsui, Janice, Yu, Rebekah, Shiwen, Xu, Selvakumar, Sadasivam, Abraham, David J., Baker, Daryll M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296231/
https://www.ncbi.nlm.nih.gov/pubmed/22462027
http://dx.doi.org/10.1155/2012/213785
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author Joshi, Dhiraj
Tsui, Janice
Yu, Rebekah
Shiwen, Xu
Selvakumar, Sadasivam
Abraham, David J.
Baker, Daryll M.
author_facet Joshi, Dhiraj
Tsui, Janice
Yu, Rebekah
Shiwen, Xu
Selvakumar, Sadasivam
Abraham, David J.
Baker, Daryll M.
author_sort Joshi, Dhiraj
collection PubMed
description Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and safety. This paper summarizes the development in EPO derivatives with emphasis on their potential use in critical limb ischaemia.
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spelling pubmed-32962312012-03-29 Potential of Novel EPO Derivatives in Limb Ischemia Joshi, Dhiraj Tsui, Janice Yu, Rebekah Shiwen, Xu Selvakumar, Sadasivam Abraham, David J. Baker, Daryll M. Cardiol Res Pract Review Article Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and safety. This paper summarizes the development in EPO derivatives with emphasis on their potential use in critical limb ischaemia. Hindawi Publishing Corporation 2012 2012-02-22 /pmc/articles/PMC3296231/ /pubmed/22462027 http://dx.doi.org/10.1155/2012/213785 Text en Copyright © 2012 Dhiraj Joshi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Joshi, Dhiraj
Tsui, Janice
Yu, Rebekah
Shiwen, Xu
Selvakumar, Sadasivam
Abraham, David J.
Baker, Daryll M.
Potential of Novel EPO Derivatives in Limb Ischemia
title Potential of Novel EPO Derivatives in Limb Ischemia
title_full Potential of Novel EPO Derivatives in Limb Ischemia
title_fullStr Potential of Novel EPO Derivatives in Limb Ischemia
title_full_unstemmed Potential of Novel EPO Derivatives in Limb Ischemia
title_short Potential of Novel EPO Derivatives in Limb Ischemia
title_sort potential of novel epo derivatives in limb ischemia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296231/
https://www.ncbi.nlm.nih.gov/pubmed/22462027
http://dx.doi.org/10.1155/2012/213785
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