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Stereotactic Irradiation of GH-Secreting Pituitary Adenomas
Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10–15 years. Despi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296430/ https://www.ncbi.nlm.nih.gov/pubmed/22518123 http://dx.doi.org/10.1155/2012/482861 |
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author | Minniti, G. Scaringi, C. Amelio, D. Maurizi Enrici, R. |
author_facet | Minniti, G. Scaringi, C. Amelio, D. Maurizi Enrici, R. |
author_sort | Minniti, G. |
collection | PubMed |
description | Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10–15 years. Despite the excellent tumour control, conventional RT is associated with a potential risk of developing late toxicity, especially hypopituitarism, and its role in the management of patients with GH-secreting pituitary adenomas remains a matter of debate. Stereotactic techniques have been developed with the aim to deliver more localized irradiation and minimize the long-term consequences of treatment, while improving its efficacy. Stereotactic irradiation can be given in a single dose as stereotactic radiosurgery (SRS) or in multiple doses as fractionated stereotactic radiotherapy (FSRT). We have reviewed the recent published literature on stereotactic techniques for GH-secreting pituitary tumors with the aim to define the efficacy and potential adverse effects of each of these techniques. |
format | Online Article Text |
id | pubmed-3296430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32964302012-04-19 Stereotactic Irradiation of GH-Secreting Pituitary Adenomas Minniti, G. Scaringi, C. Amelio, D. Maurizi Enrici, R. Int J Endocrinol Review Article Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10–15 years. Despite the excellent tumour control, conventional RT is associated with a potential risk of developing late toxicity, especially hypopituitarism, and its role in the management of patients with GH-secreting pituitary adenomas remains a matter of debate. Stereotactic techniques have been developed with the aim to deliver more localized irradiation and minimize the long-term consequences of treatment, while improving its efficacy. Stereotactic irradiation can be given in a single dose as stereotactic radiosurgery (SRS) or in multiple doses as fractionated stereotactic radiotherapy (FSRT). We have reviewed the recent published literature on stereotactic techniques for GH-secreting pituitary tumors with the aim to define the efficacy and potential adverse effects of each of these techniques. Hindawi Publishing Corporation 2012 2012-02-22 /pmc/articles/PMC3296430/ /pubmed/22518123 http://dx.doi.org/10.1155/2012/482861 Text en Copyright © 2012 G. Minniti et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Minniti, G. Scaringi, C. Amelio, D. Maurizi Enrici, R. Stereotactic Irradiation of GH-Secreting Pituitary Adenomas |
title | Stereotactic Irradiation of GH-Secreting Pituitary Adenomas |
title_full | Stereotactic Irradiation of GH-Secreting Pituitary Adenomas |
title_fullStr | Stereotactic Irradiation of GH-Secreting Pituitary Adenomas |
title_full_unstemmed | Stereotactic Irradiation of GH-Secreting Pituitary Adenomas |
title_short | Stereotactic Irradiation of GH-Secreting Pituitary Adenomas |
title_sort | stereotactic irradiation of gh-secreting pituitary adenomas |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296430/ https://www.ncbi.nlm.nih.gov/pubmed/22518123 http://dx.doi.org/10.1155/2012/482861 |
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