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Stereotactic Irradiation of GH-Secreting Pituitary Adenomas

Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10–15 years. Despi...

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Detalles Bibliográficos
Autores principales: Minniti, G., Scaringi, C., Amelio, D., Maurizi Enrici, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296430/
https://www.ncbi.nlm.nih.gov/pubmed/22518123
http://dx.doi.org/10.1155/2012/482861
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author Minniti, G.
Scaringi, C.
Amelio, D.
Maurizi Enrici, R.
author_facet Minniti, G.
Scaringi, C.
Amelio, D.
Maurizi Enrici, R.
author_sort Minniti, G.
collection PubMed
description Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10–15 years. Despite the excellent tumour control, conventional RT is associated with a potential risk of developing late toxicity, especially hypopituitarism, and its role in the management of patients with GH-secreting pituitary adenomas remains a matter of debate. Stereotactic techniques have been developed with the aim to deliver more localized irradiation and minimize the long-term consequences of treatment, while improving its efficacy. Stereotactic irradiation can be given in a single dose as stereotactic radiosurgery (SRS) or in multiple doses as fractionated stereotactic radiotherapy (FSRT). We have reviewed the recent published literature on stereotactic techniques for GH-secreting pituitary tumors with the aim to define the efficacy and potential adverse effects of each of these techniques.
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spelling pubmed-32964302012-04-19 Stereotactic Irradiation of GH-Secreting Pituitary Adenomas Minniti, G. Scaringi, C. Amelio, D. Maurizi Enrici, R. Int J Endocrinol Review Article Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10–15 years. Despite the excellent tumour control, conventional RT is associated with a potential risk of developing late toxicity, especially hypopituitarism, and its role in the management of patients with GH-secreting pituitary adenomas remains a matter of debate. Stereotactic techniques have been developed with the aim to deliver more localized irradiation and minimize the long-term consequences of treatment, while improving its efficacy. Stereotactic irradiation can be given in a single dose as stereotactic radiosurgery (SRS) or in multiple doses as fractionated stereotactic radiotherapy (FSRT). We have reviewed the recent published literature on stereotactic techniques for GH-secreting pituitary tumors with the aim to define the efficacy and potential adverse effects of each of these techniques. Hindawi Publishing Corporation 2012 2012-02-22 /pmc/articles/PMC3296430/ /pubmed/22518123 http://dx.doi.org/10.1155/2012/482861 Text en Copyright © 2012 G. Minniti et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Minniti, G.
Scaringi, C.
Amelio, D.
Maurizi Enrici, R.
Stereotactic Irradiation of GH-Secreting Pituitary Adenomas
title Stereotactic Irradiation of GH-Secreting Pituitary Adenomas
title_full Stereotactic Irradiation of GH-Secreting Pituitary Adenomas
title_fullStr Stereotactic Irradiation of GH-Secreting Pituitary Adenomas
title_full_unstemmed Stereotactic Irradiation of GH-Secreting Pituitary Adenomas
title_short Stereotactic Irradiation of GH-Secreting Pituitary Adenomas
title_sort stereotactic irradiation of gh-secreting pituitary adenomas
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296430/
https://www.ncbi.nlm.nih.gov/pubmed/22518123
http://dx.doi.org/10.1155/2012/482861
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