Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

BACKGROUND: Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously reported that loss of LRRK2 causes impairment of protein degradation pathway...

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Detalles Bibliográficos
Autores principales: Tong, Youren, Giaime, Emilie, Yamaguchi, Hiroo, Ichimura, Takaharu, Liu, Yumin, Si, Huiqing, Cai, Huaibin, Bonventre, Joseph V, Shen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296570/
https://www.ncbi.nlm.nih.gov/pubmed/22230652
http://dx.doi.org/10.1186/1750-1326-7-2

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