Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics

Ginsenosides, the bioactive components of ginseng, can be divided into two major groups, namely 20(S)-protopanaxatriol (e.g. Re, Rg(1), Rg(2), and Rb(3)) and 20(S)-protopanaxadiol (e.g. Rb(1), Rb(2), Rc, and Rd). Biological and environmental factors may affect the content of ginsenosides in differen...

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Detalles Bibliográficos
Autores principales: Peng, Dacheng, Wang, Huashan, Qu, Chenling, Xie, Laihua, Wicks, Sheila M, Xie, Jingtian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296575/
https://www.ncbi.nlm.nih.gov/pubmed/22314249
http://dx.doi.org/10.1186/1749-8546-7-2
Descripción
Sumario:Ginsenosides, the bioactive components of ginseng, can be divided into two major groups, namely 20(S)-protopanaxatriol (e.g. Re, Rg(1), Rg(2), and Rb(3)) and 20(S)-protopanaxadiol (e.g. Rb(1), Rb(2), Rc, and Rd). Biological and environmental factors may affect the content of ginsenosides in different parts of ginseng plant. Evidence from pharmacokinetic and metabolic studies of Re demonstrated that (1) the absorption of Re is fast in gastrointestinal tract; (2) Re may be metabolized mainly to Rh(1 )and F(1 )by intestinal microflora before absorption into blood; and (3) Re is quickly cleared from the body.

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