Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics

Ginsenosides, the bioactive components of ginseng, can be divided into two major groups, namely 20(S)-protopanaxatriol (e.g. Re, Rg(1), Rg(2), and Rb(3)) and 20(S)-protopanaxadiol (e.g. Rb(1), Rb(2), Rc, and Rd). Biological and environmental factors may affect the content of ginsenosides in differen...

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Autores principales: Peng, Dacheng, Wang, Huashan, Qu, Chenling, Xie, Laihua, Wicks, Sheila M, Xie, Jingtian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296575/
https://www.ncbi.nlm.nih.gov/pubmed/22314249
http://dx.doi.org/10.1186/1749-8546-7-2
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author Peng, Dacheng
Wang, Huashan
Qu, Chenling
Xie, Laihua
Wicks, Sheila M
Xie, Jingtian
author_facet Peng, Dacheng
Wang, Huashan
Qu, Chenling
Xie, Laihua
Wicks, Sheila M
Xie, Jingtian
author_sort Peng, Dacheng
collection PubMed
description Ginsenosides, the bioactive components of ginseng, can be divided into two major groups, namely 20(S)-protopanaxatriol (e.g. Re, Rg(1), Rg(2), and Rb(3)) and 20(S)-protopanaxadiol (e.g. Rb(1), Rb(2), Rc, and Rd). Biological and environmental factors may affect the content of ginsenosides in different parts of ginseng plant. Evidence from pharmacokinetic and metabolic studies of Re demonstrated that (1) the absorption of Re is fast in gastrointestinal tract; (2) Re may be metabolized mainly to Rh(1 )and F(1 )by intestinal microflora before absorption into blood; and (3) Re is quickly cleared from the body.
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spelling pubmed-32965752012-03-08 Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics Peng, Dacheng Wang, Huashan Qu, Chenling Xie, Laihua Wicks, Sheila M Xie, Jingtian Chin Med Review Ginsenosides, the bioactive components of ginseng, can be divided into two major groups, namely 20(S)-protopanaxatriol (e.g. Re, Rg(1), Rg(2), and Rb(3)) and 20(S)-protopanaxadiol (e.g. Rb(1), Rb(2), Rc, and Rd). Biological and environmental factors may affect the content of ginsenosides in different parts of ginseng plant. Evidence from pharmacokinetic and metabolic studies of Re demonstrated that (1) the absorption of Re is fast in gastrointestinal tract; (2) Re may be metabolized mainly to Rh(1 )and F(1 )by intestinal microflora before absorption into blood; and (3) Re is quickly cleared from the body. BioMed Central 2012-02-07 /pmc/articles/PMC3296575/ /pubmed/22314249 http://dx.doi.org/10.1186/1749-8546-7-2 Text en Copyright ©2012 Peng et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Peng, Dacheng
Wang, Huashan
Qu, Chenling
Xie, Laihua
Wicks, Sheila M
Xie, Jingtian
Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics
title Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics
title_full Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics
title_fullStr Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics
title_full_unstemmed Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics
title_short Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics
title_sort ginsenoside re: its chemistry, metabolism and pharmacokinetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296575/
https://www.ncbi.nlm.nih.gov/pubmed/22314249
http://dx.doi.org/10.1186/1749-8546-7-2
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