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Prolyl Isomerase Pin1 Regulates Mouse Embryonic Fibroblast Differentiation into Adipose Cells
BACKGROUND: A peptidyl prolyl cis/trans isomerase, Pin1, regulates insulin signal transduction. Pin1 reduces responses to insulin stimulation by binding CRTC2 (CREB-regulated transcriptional co-activator 2) and PPARγ (peroxisome prolifereator- activated receptor γ), but conversely enhances insulin s...
Autores principales: | Uchida, Takafumi, Furumai, Kengo, Fukuda, Tomokazu, Akiyama, Hirotada, Takezawa, Mika, Asano, Tomoichiro, Fujimori, Fumihiro, Uchida, Chiyoko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296696/ https://www.ncbi.nlm.nih.gov/pubmed/22412843 http://dx.doi.org/10.1371/journal.pone.0031823 |
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