Lung Adenocarcinoma of Never Smokers and Smokers Harbor Differential Regions of Genetic Alteration and Exhibit Different Levels of Genomic Instability

Recent evidence suggests that the observed clinical distinctions between lung tumors in smokers and never smokers (NS) extend beyond specific gene mutations, such as EGFR, EML4-ALK, and KRAS, some of which have been translated into targeted therapies. However, the molecular alterations identified th...

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Detalles Bibliográficos
Autores principales: Thu, Kelsie L., Vucic, Emily A., Chari, Raj, Zhang, Wei, Lockwood, William W., English, John C., Fu, Rong, Wang, Pei, Feng, Ziding, MacAulay, Calum E., Gazdar, Adi F., Lam, Stephen, Lam, Wan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296775/
https://www.ncbi.nlm.nih.gov/pubmed/22412972
http://dx.doi.org/10.1371/journal.pone.0033003

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