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Investigation of the Mechanism of Clearance of AMG 386, a Selective Angiopoietin-1/2 Neutralizing Peptibody, in Splenectomized, Nephrectomized, and FcRn Knockout Rodent Models

PURPOSE: To investigate the mechanisms of clearance of AMG 386, an investigational recombinant peptide-Fc fusion protein (peptibody) that blocks tumor angiogenesis by neutralizing the interaction between angiopoietin-1 and -2 and the Tie2 receptor. METHODS: The role of the neonatal Fc receptor (FcRn...

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Detalles Bibliográficos
Autores principales:	Wu, Benjamin, Johnson, Jessica, Soto, Marcus, Ponce, Manuel, Calamba, Dominador, Sun, Yu-Nien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2011
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296951/ https://www.ncbi.nlm.nih.gov/pubmed/22189693 http://dx.doi.org/10.1007/s11095-011-0650-z

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