New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae

Six new cembranolides, michaolides L–Q (1–6), and a known cembranolide, lobomichaolide (7) were isolated from the CH(2)Cl(2) extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1–7 and the...

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Detalles Bibliográficos
Autores principales: Wang, Shang-Kwei, Duh, Chang-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296998/
https://www.ncbi.nlm.nih.gov/pubmed/22412802
http://dx.doi.org/10.3390/md10020306
Descripción
Sumario:Six new cembranolides, michaolides L–Q (1–6), and a known cembranolide, lobomichaolide (7) were isolated from the CH(2)Cl(2) extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1–7 and their cytotoxicity against selected cell lines were evaluated.

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