New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae

Six new cembranolides, michaolides L–Q (1–6), and a known cembranolide, lobomichaolide (7) were isolated from the CH(2)Cl(2) extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1–7 and the...

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Detalles Bibliográficos
Autores principales: Wang, Shang-Kwei, Duh, Chang-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296998/
https://www.ncbi.nlm.nih.gov/pubmed/22412802
http://dx.doi.org/10.3390/md10020306
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author Wang, Shang-Kwei
Duh, Chang-Yih
author_facet Wang, Shang-Kwei
Duh, Chang-Yih
author_sort Wang, Shang-Kwei
collection PubMed
description Six new cembranolides, michaolides L–Q (1–6), and a known cembranolide, lobomichaolide (7) were isolated from the CH(2)Cl(2) extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1–7 and their cytotoxicity against selected cell lines were evaluated.
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spelling pubmed-32969982012-03-12 New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae Wang, Shang-Kwei Duh, Chang-Yih Mar Drugs Article Six new cembranolides, michaolides L–Q (1–6), and a known cembranolide, lobomichaolide (7) were isolated from the CH(2)Cl(2) extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1–7 and their cytotoxicity against selected cell lines were evaluated. MDPI 2012-01-31 /pmc/articles/PMC3296998/ /pubmed/22412802 http://dx.doi.org/10.3390/md10020306 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Shang-Kwei
Duh, Chang-Yih
New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae
title New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae
title_full New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae
title_fullStr New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae
title_full_unstemmed New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae
title_short New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae
title_sort new cytotoxic cembranolides from the soft coral lobophytum michaelae
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296998/
https://www.ncbi.nlm.nih.gov/pubmed/22412802
http://dx.doi.org/10.3390/md10020306
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