Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321

Three new eremophilane sesquiterpenes (1–3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 s...

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Detalles Bibliográficos
Autores principales: Song, Yongxiang, Wang, Jiajian, Huang, Hongbo, Ma, Lin, Wang, Jun, Gu, Yucheng, Liu, Lan, Lin, Yongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297001/
https://www.ncbi.nlm.nih.gov/pubmed/22412805
http://dx.doi.org/10.3390/md10020340
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author Song, Yongxiang
Wang, Jiajian
Huang, Hongbo
Ma, Lin
Wang, Jun
Gu, Yucheng
Liu, Lan
Lin, Yongcheng
author_facet Song, Yongxiang
Wang, Jiajian
Huang, Hongbo
Ma, Lin
Wang, Jun
Gu, Yucheng
Liu, Lan
Lin, Yongcheng
author_sort Song, Yongxiang
collection PubMed
description Three new eremophilane sesquiterpenes (1–3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC(50) value is 6.54 μM.
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spelling pubmed-32970012012-03-12 Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321 Song, Yongxiang Wang, Jiajian Huang, Hongbo Ma, Lin Wang, Jun Gu, Yucheng Liu, Lan Lin, Yongcheng Mar Drugs Article Three new eremophilane sesquiterpenes (1–3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC(50) value is 6.54 μM. MDPI 2012-02-06 /pmc/articles/PMC3297001/ /pubmed/22412805 http://dx.doi.org/10.3390/md10020340 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Song, Yongxiang
Wang, Jiajian
Huang, Hongbo
Ma, Lin
Wang, Jun
Gu, Yucheng
Liu, Lan
Lin, Yongcheng
Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321
title Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321
title_full Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321
title_fullStr Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321
title_full_unstemmed Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321
title_short Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321
title_sort four eremophilane sesquiterpenes from the mangrove endophytic fungus xylaria sp. bl321
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297001/
https://www.ncbi.nlm.nih.gov/pubmed/22412805
http://dx.doi.org/10.3390/md10020340
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