Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension

Antihypertensive effect of long-term oral administration of jellyfish (Rhopilema esculentum) collagen peptides (JCP) on renovascular hypertension rats (RVHs) was evaluated. The systolic blood pressure and diastolic blood pressure of the RVHs were significantly reduced with administration of JCP (p &...

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Detalles Bibliográficos
Autores principales: Zhuang, Yongliang, Sun, Liping, Zhang, Yufeng, Liu, Gaoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297005/
https://www.ncbi.nlm.nih.gov/pubmed/22412809
http://dx.doi.org/10.3390/md10020417
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author Zhuang, Yongliang
Sun, Liping
Zhang, Yufeng
Liu, Gaoxiang
author_facet Zhuang, Yongliang
Sun, Liping
Zhang, Yufeng
Liu, Gaoxiang
author_sort Zhuang, Yongliang
collection PubMed
description Antihypertensive effect of long-term oral administration of jellyfish (Rhopilema esculentum) collagen peptides (JCP) on renovascular hypertension rats (RVHs) was evaluated. The systolic blood pressure and diastolic blood pressure of the RVHs were significantly reduced with administration of JCP (p < 0.05), compared with model control group. However, the arterial blood pressure of normal rats showed no significant changes during long-term oral treatment with high dose JCP (p > 0.05). Furthermore, effect of JCP on angiotensin II (Ang II) concentration of plasma had no significance (p > 0.05), but JCP significantly inhibited the Ang II concentration in RVHs’ kidney (p < 0.05). The kidney should be the target site of JCP.
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spelling pubmed-32970052012-03-12 Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension Zhuang, Yongliang Sun, Liping Zhang, Yufeng Liu, Gaoxiang Mar Drugs Communication Antihypertensive effect of long-term oral administration of jellyfish (Rhopilema esculentum) collagen peptides (JCP) on renovascular hypertension rats (RVHs) was evaluated. The systolic blood pressure and diastolic blood pressure of the RVHs were significantly reduced with administration of JCP (p < 0.05), compared with model control group. However, the arterial blood pressure of normal rats showed no significant changes during long-term oral treatment with high dose JCP (p > 0.05). Furthermore, effect of JCP on angiotensin II (Ang II) concentration of plasma had no significance (p > 0.05), but JCP significantly inhibited the Ang II concentration in RVHs’ kidney (p < 0.05). The kidney should be the target site of JCP. MDPI 2012-02-15 /pmc/articles/PMC3297005/ /pubmed/22412809 http://dx.doi.org/10.3390/md10020417 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Zhuang, Yongliang
Sun, Liping
Zhang, Yufeng
Liu, Gaoxiang
Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension
title Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension
title_full Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension
title_fullStr Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension
title_full_unstemmed Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension
title_short Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension
title_sort antihypertensive effect of long-term oral administration of jellyfish (rhopilema esculentum) collagen peptides on renovascular hypertension
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297005/
https://www.ncbi.nlm.nih.gov/pubmed/22412809
http://dx.doi.org/10.3390/md10020417
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