Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound...

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Detalles Bibliográficos
Autores principales: Lee, Cheng-Hung, Kao, Chia-Ying, Kao, Shih-Yao, Chang, Chih-Han, Su, Jui-Hsin, Hwang, Tsong-Long, Kuo, Yueh-Hsiung, Wen, Zhi-Hong, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297006/
https://www.ncbi.nlm.nih.gov/pubmed/22412810
http://dx.doi.org/10.3390/md10020427
Descripción
Sumario:A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils.

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