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Steroids from the Soft Coral Sinularia crassa

One new sterol, crassarosterol A (1), and four new steroidal glycosides, crassarosterosides A–D (2–5) were isolated from the Formosan soft coral Sinularia crassa. The absolute configuration of 1 was determined using the Mosher’s method. The absolute configurations for the sugar moieties of 2–5 were...

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Autores principales: Chao, Chih-Hua, Chou, Kuei-Ju, Huang, Chiung-Yao, Wen, Zhi-Hong, Hsu, Chi-Hsin, Wu, Yang-Chang, Dai, Chang-Feng, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297007/
https://www.ncbi.nlm.nih.gov/pubmed/22412811
http://dx.doi.org/10.3390/md10020439
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author Chao, Chih-Hua
Chou, Kuei-Ju
Huang, Chiung-Yao
Wen, Zhi-Hong
Hsu, Chi-Hsin
Wu, Yang-Chang
Dai, Chang-Feng
Sheu, Jyh-Horng
author_facet Chao, Chih-Hua
Chou, Kuei-Ju
Huang, Chiung-Yao
Wen, Zhi-Hong
Hsu, Chi-Hsin
Wu, Yang-Chang
Dai, Chang-Feng
Sheu, Jyh-Horng
author_sort Chao, Chih-Hua
collection PubMed
description One new sterol, crassarosterol A (1), and four new steroidal glycosides, crassarosterosides A–D (2–5) were isolated from the Formosan soft coral Sinularia crassa. The absolute configuration of 1 was determined using the Mosher’s method. The absolute configurations for the sugar moieties of 2–5 were determined by HPLC analysis on the o-tolylthiocarbamates derived from the liberated sugar after acid hydrolysis. Compounds 2 and 4 could significantly inhibit the expression of pro-inflammatory iNOS protein at 10 µM. In contrast, 1–3 were found to stimulate the expression of COX-2 protein at this concentration. Steroids 1 and 4 also showed cytotoxicity toward the selected human liver cancer cells.
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spelling pubmed-32970072012-03-12 Steroids from the Soft Coral Sinularia crassa Chao, Chih-Hua Chou, Kuei-Ju Huang, Chiung-Yao Wen, Zhi-Hong Hsu, Chi-Hsin Wu, Yang-Chang Dai, Chang-Feng Sheu, Jyh-Horng Mar Drugs Article One new sterol, crassarosterol A (1), and four new steroidal glycosides, crassarosterosides A–D (2–5) were isolated from the Formosan soft coral Sinularia crassa. The absolute configuration of 1 was determined using the Mosher’s method. The absolute configurations for the sugar moieties of 2–5 were determined by HPLC analysis on the o-tolylthiocarbamates derived from the liberated sugar after acid hydrolysis. Compounds 2 and 4 could significantly inhibit the expression of pro-inflammatory iNOS protein at 10 µM. In contrast, 1–3 were found to stimulate the expression of COX-2 protein at this concentration. Steroids 1 and 4 also showed cytotoxicity toward the selected human liver cancer cells. MDPI 2012-02-16 /pmc/articles/PMC3297007/ /pubmed/22412811 http://dx.doi.org/10.3390/md10020439 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chao, Chih-Hua
Chou, Kuei-Ju
Huang, Chiung-Yao
Wen, Zhi-Hong
Hsu, Chi-Hsin
Wu, Yang-Chang
Dai, Chang-Feng
Sheu, Jyh-Horng
Steroids from the Soft Coral Sinularia crassa
title Steroids from the Soft Coral Sinularia crassa
title_full Steroids from the Soft Coral Sinularia crassa
title_fullStr Steroids from the Soft Coral Sinularia crassa
title_full_unstemmed Steroids from the Soft Coral Sinularia crassa
title_short Steroids from the Soft Coral Sinularia crassa
title_sort steroids from the soft coral sinularia crassa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297007/
https://www.ncbi.nlm.nih.gov/pubmed/22412811
http://dx.doi.org/10.3390/md10020439
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