Cargando…
A Miniature Probe for Ultrasonic Penetration of a Single Cell
Although ultrasound cavitation must be avoided for safe diagnostic applications, the ability of ultrasound to disrupt cell membranes has taken on increasing significance as a method to facilitate drug and gene delivery. A new ultrasonic resonance driving method is introduced to penetrate rigid wall...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297146/ https://www.ncbi.nlm.nih.gov/pubmed/22412314 http://dx.doi.org/10.3390/s90503325 |
_version_ | 1782225828363370496 |
---|---|
author | Wu, Ting Zhou, Zhaoying Wang, Qun Yang, Xing Xiao, Mingfei |
author_facet | Wu, Ting Zhou, Zhaoying Wang, Qun Yang, Xing Xiao, Mingfei |
author_sort | Wu, Ting |
collection | PubMed |
description | Although ultrasound cavitation must be avoided for safe diagnostic applications, the ability of ultrasound to disrupt cell membranes has taken on increasing significance as a method to facilitate drug and gene delivery. A new ultrasonic resonance driving method is introduced to penetrate rigid wall plant cells or oocytes with springy cell membranes. When a reasonable design is created, ultrasound can gather energy and increase the amplitude factor. Ultrasonic penetration enables exogenous materials to enter cells without damaging them by utilizing instant acceleration. This paper seeks to develop a miniature ultrasonic probe experiment system for cell penetration. A miniature ultrasonic probe is designed and optimized using the Precise Four Terminal Network Method and Finite Element Method (FEM) and an ultrasonic generator to drive the probe is designed. The system was able to successfully puncture a single fish cell. |
format | Online Article Text |
id | pubmed-3297146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-32971462012-03-12 A Miniature Probe for Ultrasonic Penetration of a Single Cell Wu, Ting Zhou, Zhaoying Wang, Qun Yang, Xing Xiao, Mingfei Sensors (Basel) Communication Although ultrasound cavitation must be avoided for safe diagnostic applications, the ability of ultrasound to disrupt cell membranes has taken on increasing significance as a method to facilitate drug and gene delivery. A new ultrasonic resonance driving method is introduced to penetrate rigid wall plant cells or oocytes with springy cell membranes. When a reasonable design is created, ultrasound can gather energy and increase the amplitude factor. Ultrasonic penetration enables exogenous materials to enter cells without damaging them by utilizing instant acceleration. This paper seeks to develop a miniature ultrasonic probe experiment system for cell penetration. A miniature ultrasonic probe is designed and optimized using the Precise Four Terminal Network Method and Finite Element Method (FEM) and an ultrasonic generator to drive the probe is designed. The system was able to successfully puncture a single fish cell. Molecular Diversity Preservation International (MDPI) 2009-05-06 /pmc/articles/PMC3297146/ /pubmed/22412314 http://dx.doi.org/10.3390/s90503325 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Communication Wu, Ting Zhou, Zhaoying Wang, Qun Yang, Xing Xiao, Mingfei A Miniature Probe for Ultrasonic Penetration of a Single Cell |
title | A Miniature Probe for Ultrasonic Penetration of a Single Cell |
title_full | A Miniature Probe for Ultrasonic Penetration of a Single Cell |
title_fullStr | A Miniature Probe for Ultrasonic Penetration of a Single Cell |
title_full_unstemmed | A Miniature Probe for Ultrasonic Penetration of a Single Cell |
title_short | A Miniature Probe for Ultrasonic Penetration of a Single Cell |
title_sort | miniature probe for ultrasonic penetration of a single cell |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297146/ https://www.ncbi.nlm.nih.gov/pubmed/22412314 http://dx.doi.org/10.3390/s90503325 |
work_keys_str_mv | AT wuting aminiatureprobeforultrasonicpenetrationofasinglecell AT zhouzhaoying aminiatureprobeforultrasonicpenetrationofasinglecell AT wangqun aminiatureprobeforultrasonicpenetrationofasinglecell AT yangxing aminiatureprobeforultrasonicpenetrationofasinglecell AT xiaomingfei aminiatureprobeforultrasonicpenetrationofasinglecell AT wuting miniatureprobeforultrasonicpenetrationofasinglecell AT zhouzhaoying miniatureprobeforultrasonicpenetrationofasinglecell AT wangqun miniatureprobeforultrasonicpenetrationofasinglecell AT yangxing miniatureprobeforultrasonicpenetrationofasinglecell AT xiaomingfei miniatureprobeforultrasonicpenetrationofasinglecell |