Epitope Flexibility and Dynamic Footprint Revealed by Molecular Dynamics of a pMHC-TCR Complex

The crystal structures of unliganded and liganded pMHC molecules provide a structural basis for TCR recognition yet they represent ‘snapshots’ and offer limited insight into dynamics that may be important for interaction and T cell activation. MHC molecules HLA-B*3501 and HLA-B*3508 both bind a 13 m...

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Detalles Bibliográficos
Autores principales: Reboul, Cyril F., Meyer, Grischa R., Porebski, Benjamin T., Borg, Natalie A., Buckle, Ashley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297556/
https://www.ncbi.nlm.nih.gov/pubmed/22412359
http://dx.doi.org/10.1371/journal.pcbi.1002404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297556/
https://www.ncbi.nlm.nih.gov/pubmed/22412359
http://dx.doi.org/10.1371/journal.pcbi.1002404

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