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Identification of ORC1/CDC6-Interacting Factors in Trypanosoma brucei Reveals Critical Features of Origin Recognition Complex Architecture
DNA Replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with Cdt1. Eukaryotic ORC is considered to be composed...
Autores principales: | Tiengwe, Calvin, Marcello, Lucio, Farr, Helen, Gadelha, Catarina, Burchmore, Richard, Barry, J. David, Bell, Stephen D., McCulloch, Richard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297607/ https://www.ncbi.nlm.nih.gov/pubmed/22412905 http://dx.doi.org/10.1371/journal.pone.0032674 |
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