Cargando…

Piezos are pore-forming subunits of mechanically activated channels

Mechanotransduction plays a crucial role in physiology. Biological processes including sensing touch and sound waves require yet unidentified cation channels that detect pressure. Mouse piezo1 (mpiezo1) and mpiezo2 induce mechanically activated cationic currents in cells; however, it is unknown if p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coste, Bertrand, Xiao, Bailong, Santos, Jose S., Syeda, Ruhma, Grandl, Jörg, Spencer, Kathryn S., Kim, Sung Eun, Schmidt, Manuela, Mathur, Jayanti, Dubin, Adrienne E., Montal, Mauricio, Patapoutian, Ardem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297710/ https://www.ncbi.nlm.nih.gov/pubmed/22343900 http://dx.doi.org/10.1038/nature10812

Ejemplares similares

Chemical activation of the mechanotransduction channel Piezo1
por: Syeda, Ruhma, et al.
Publicado: (2015)

Piezo1 ion channel pore properties are dictated by C-terminal region
por: Coste, Bertrand, et al.
Publicado: (2015)

Temperature-dependent STIM1 activation induces Ca(2+) influx and modulates gene expression
por: Xiao, Bailong, et al.
Publicado: (2011)

The role of Drosophila Piezo in mechanical nociception
por: Kim, Sung Eun, et al.
Publicado: (2012)

Single Residues in the Outer Pore of TRPV1 and TRPV3 Have Temperature-Dependent Conformations
por: Kim, Sung Eun, et al.
Publicado: (2013)

PIEZO1 transduces mechanical itch in mice
por: Hill, Rose Z., et al.
Publicado: (2022)

Identification and functional characterization of the Piezo1 channel pore domain
por: Nosyreva, Elena. D., et al.
Publicado: (2020)

Direct observation of the conformational states of PIEZO1
por: Mulhall, Eric M., et al.
Publicado: (2023)

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain
por: Grandl, Jörg, et al.
Publicado: (2010)

Piezo2 is required for Merkel cell mechanotransduction
por: Woo, Seung-Hyun, et al.
Publicado: (2014)

Dehydrated Hereditary Stomatocytosislinked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
por: Albuisson, Juliette, et al.
Publicado: (2013)

TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice
por: Miyamoto, Takashi, et al.
Publicado: (2009)

Piezo1 links mechanical forces to red blood cell volume
por: Cahalan, Stuart M, et al.
Publicado: (2015)

Reevaluation of Piezo1 as a gut RNA sensor
por: Nickolls, Alec R, et al.
Publicado: (2022)

Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia
por: Lukacs, Viktor, et al.
Publicado: (2015)

Physics of mechanotransduction by Piezo ion channels
por: Young, Michael, et al.
Publicado: (2022)

Piezo2 is the principal mechanotransduction channel for proprioception
por: Woo, Seung-Hyun, et al.
Publicado: (2015)

Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix
por: Wu, Jason, et al.
Publicado: (2017)

Piezo1 ion channels inherently function as independent mechanotransducers
por: Lewis, Amanda H, et al.
Publicado: (2021)

Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
por: Nonomura, Keiko, et al.
Publicado: (2018)

Localized force application reveals mechanically sensitive domains of Piezo1
por: Wu, Jason, et al.
Publicado: (2016)

PIEZO2 in sensory neurons and urothelial cells coordinates urination
por: Marshall, Kara L., et al.
Publicado: (2020)

Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension
por: Lewis, Amanda H, et al.
Publicado: (2015)

Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing
por: Holt, Jesse R, et al.
Publicado: (2021)

Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap
por: Lewis, Amanda H., et al.
Publicado: (2020)

Correction: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing
por: Holt, Jesse R, et al.
Publicado: (2022)

PIEZO2 in somatosensory neurons controls gastrointestinal transit
por: Servin-Vences, M. Rocio, et al.
Publicado: (2023)

Investigation of associations between Piezo1 mechanoreceptor gain-of-function variants and glaucoma-related phenotypes in humans and mice
por: Baxter, Sally L., et al.
Publicado: (2020)

OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels
por: Murthy, Swetha E, et al.
Publicado: (2018)

A protein interaction mechanism for suppressing the mechanosensitive Piezo channels
por: Zhang, Tingxin, et al.
Publicado: (2017)

The Pore-Domain of TRPA1 Mediates the Inhibitory Effect of the Antagonist 6-Methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole
por: Moldenhauer, Hans, et al.
Publicado: (2014)

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels
por: Wu, Zizhen, et al.
Publicado: (2016)

Piezo1–Pannexin1 complex couples force detection to ATP secretion in cholangiocytes
por: Desplat, Angélique, et al.
Publicado: (2021)

The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
por: Jiang, Fan, et al.
Publicado: (2021)

Molecular Template for a Voltage Sensor in a Novel K(+) Channel. III. Functional Reconstitution of a Sensorless Pore Module from a Prokaryotic Kv Channel
por: Santos, Jose S., et al.
Publicado: (2008)

Structure of the human volume regulated anion channel
por: Kefauver, Jennifer M, et al.
Publicado: (2018)

A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
por: Zheng, Wang, et al.
Publicado: (2019)

S-Acylation controls functional coupling of BK channel pore-forming α-subunits and β1-subunits
por: Duncan, Peter J., et al.
Publicado: (2019)

The mechanosensitive Piezo1 channel is required for bone formation
por: Sun, Weijia, et al.
Publicado: (2019)

Hybrid Piezo/Magnetic Electromechanical Transformer
por: Rendon-Hernandez, Adrian A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uuauelij7d1vs1sa7k9ejmcn56