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8-Benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one
In the title methaqualone analogue, C(23)H(20)N(2)O(2), the planes of the terminal aromatic rings [dihedral angle between them = 64.52 (7)°] approximately face the fused-ring methyl group and both are twisted with respect to the pyrimidine plane (r.m.s. deviation = 0.028 Å), forming dihedral angles...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297916/ https://www.ncbi.nlm.nih.gov/pubmed/22412719 http://dx.doi.org/10.1107/S1600536812007362 |
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author | El-Azab, Adel S. Abdel-Aziz, Alaa A.-M. Ng, Seik Weng Tiekink, Edward R. T. |
author_facet | El-Azab, Adel S. Abdel-Aziz, Alaa A.-M. Ng, Seik Weng Tiekink, Edward R. T. |
author_sort | El-Azab, Adel S. |
collection | PubMed |
description | In the title methaqualone analogue, C(23)H(20)N(2)O(2), the planes of the terminal aromatic rings [dihedral angle between them = 64.52 (7)°] approximately face the fused-ring methyl group and both are twisted with respect to the pyrimidine plane (r.m.s. deviation = 0.028 Å), forming dihedral angles of 86.9 (3) (with the 2-tolyl ring) and 65.57 (7)°. The 2-tolyl residue is disordered over two almost coplanar but opposite orientations with the major component having a site-occupancy factor of 0.893 (3). The three-dimensional crystal packing is consolidated by C—H⋯O, C—H⋯π and π–π [2-tolyl–2-tolyl centroid–centroid distance = 3.8099 (6) Å] interactions. |
format | Online Article Text |
id | pubmed-3297916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-32979162012-03-12 8-Benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one El-Azab, Adel S. Abdel-Aziz, Alaa A.-M. Ng, Seik Weng Tiekink, Edward R. T. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title methaqualone analogue, C(23)H(20)N(2)O(2), the planes of the terminal aromatic rings [dihedral angle between them = 64.52 (7)°] approximately face the fused-ring methyl group and both are twisted with respect to the pyrimidine plane (r.m.s. deviation = 0.028 Å), forming dihedral angles of 86.9 (3) (with the 2-tolyl ring) and 65.57 (7)°. The 2-tolyl residue is disordered over two almost coplanar but opposite orientations with the major component having a site-occupancy factor of 0.893 (3). The three-dimensional crystal packing is consolidated by C—H⋯O, C—H⋯π and π–π [2-tolyl–2-tolyl centroid–centroid distance = 3.8099 (6) Å] interactions. International Union of Crystallography 2012-02-29 /pmc/articles/PMC3297916/ /pubmed/22412719 http://dx.doi.org/10.1107/S1600536812007362 Text en © El-Azab et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers El-Azab, Adel S. Abdel-Aziz, Alaa A.-M. Ng, Seik Weng Tiekink, Edward R. T. 8-Benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one |
title | 8-Benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one |
title_full | 8-Benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one |
title_fullStr | 8-Benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one |
title_full_unstemmed | 8-Benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one |
title_short | 8-Benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one |
title_sort | 8-benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3h)-one |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297916/ https://www.ncbi.nlm.nih.gov/pubmed/22412719 http://dx.doi.org/10.1107/S1600536812007362 |
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