Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic

We investigated multidrug-resistant (MDR) Mycobacterium tuberculosis strains in Bangui, Central African Republic. We found 39.6% with the same spoligotype and synonymous single nucleotide polymorphism in the mutT1 gene. However, strains had different rpoB mutations responsible for rifampin resistanc...

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Detalles Bibliográficos
Autores principales: Nouvel, Laurent X., Kassa-Kelembho, Eric, Dos Vultos, Tiago, Zandanga, Germain, Rauzier, Jean, Lafoz, Carmen, Martin, Carlos, Blazquez, Jesus, Talarmin, Antoine, Gicquel, Brigitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2006
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298286/
https://www.ncbi.nlm.nih.gov/pubmed/17073103
http://dx.doi.org/10.3201/eid1209.060361
Descripción
Sumario:We investigated multidrug-resistant (MDR) Mycobacterium tuberculosis strains in Bangui, Central African Republic. We found 39.6% with the same spoligotype and synonymous single nucleotide polymorphism in the mutT1 gene. However, strains had different rpoB mutations responsible for rifampin resistance. MDR strains in Bangui may emerge preferentially from a single, MDR-prone family.

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