The multifunctional poly(A)-binding protein (PABP) 1 is subject to extensive dynamic post-translational modification, which molecular modelling suggests plays an important role in co-ordinating its activities

PABP1 [poly(A)-binding protein 1] is a central regulator of mRNA translation and stability and is required for miRNA (microRNA)-mediated regulation and nonsense-mediated decay. Numerous protein, as well as RNA, interactions underlie its multi-functional nature; however, it is unclear how its differe...

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Detalles Bibliográficos
Autores principales: Brook, Matthew, McCracken, Lora, Reddington, James P., Lu, Zhi-Liang, Morrice, Nicholas A., Gray, Nicola K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298439/
https://www.ncbi.nlm.nih.gov/pubmed/22004688
http://dx.doi.org/10.1042/BJ20111474

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