Effects of Dopamine on Sensitivity to Social Bias in Parkinson's Disease

Patients with Parkinson's disease (PD) sometimes develop impulsive compulsive behaviours (ICBs) due to their dopaminergic medication. We compared 26 impulsive and 27 non-impulsive patients with PD, both on and off medication, on a task that examined emotion bias in decision making. No group dif...

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Autores principales: Djamshidian, Atbin, O'Sullivan, Sean S., Lees, Andrew, Averbeck, Bruno B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298454/
https://www.ncbi.nlm.nih.gov/pubmed/22427905
http://dx.doi.org/10.1371/journal.pone.0032889
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author Djamshidian, Atbin
O'Sullivan, Sean S.
Lees, Andrew
Averbeck, Bruno B.
author_facet Djamshidian, Atbin
O'Sullivan, Sean S.
Lees, Andrew
Averbeck, Bruno B.
author_sort Djamshidian, Atbin
collection PubMed
description Patients with Parkinson's disease (PD) sometimes develop impulsive compulsive behaviours (ICBs) due to their dopaminergic medication. We compared 26 impulsive and 27 non-impulsive patients with PD, both on and off medication, on a task that examined emotion bias in decision making. No group differences were detected, but patients on medication were less biased by emotions than patients off medication and the strongest effects were seen in patients with ICBs. PD patients with ICBs on medication also showed more learning from negative feedback and less from positive feedback, whereas off medication they showed the opposite effect.
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spelling pubmed-32984542012-03-16 Effects of Dopamine on Sensitivity to Social Bias in Parkinson's Disease Djamshidian, Atbin O'Sullivan, Sean S. Lees, Andrew Averbeck, Bruno B. PLoS One Research Article Patients with Parkinson's disease (PD) sometimes develop impulsive compulsive behaviours (ICBs) due to their dopaminergic medication. We compared 26 impulsive and 27 non-impulsive patients with PD, both on and off medication, on a task that examined emotion bias in decision making. No group differences were detected, but patients on medication were less biased by emotions than patients off medication and the strongest effects were seen in patients with ICBs. PD patients with ICBs on medication also showed more learning from negative feedback and less from positive feedback, whereas off medication they showed the opposite effect. Public Library of Science 2012-03-09 /pmc/articles/PMC3298454/ /pubmed/22427905 http://dx.doi.org/10.1371/journal.pone.0032889 Text en This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Djamshidian, Atbin
O'Sullivan, Sean S.
Lees, Andrew
Averbeck, Bruno B.
Effects of Dopamine on Sensitivity to Social Bias in Parkinson's Disease
title Effects of Dopamine on Sensitivity to Social Bias in Parkinson's Disease
title_full Effects of Dopamine on Sensitivity to Social Bias in Parkinson's Disease
title_fullStr Effects of Dopamine on Sensitivity to Social Bias in Parkinson's Disease
title_full_unstemmed Effects of Dopamine on Sensitivity to Social Bias in Parkinson's Disease
title_short Effects of Dopamine on Sensitivity to Social Bias in Parkinson's Disease
title_sort effects of dopamine on sensitivity to social bias in parkinson's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298454/
https://www.ncbi.nlm.nih.gov/pubmed/22427905
http://dx.doi.org/10.1371/journal.pone.0032889
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