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Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles

BACKGROUND: Gene transfer using non-viral vectors offers a non-immunogenic and safe method of gene delivery. Cellular uptake and intracellular trafficking of the nanoparticles can impact on the transfection efficiency of these vectors. Therefore, understanding the physicochemical properties that may...

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Detalles Bibliográficos
Autores principales:	Singh, Jagbir, Michel, Deborah, Chitanda, Jackson M, Verrall, Ronald E, Badea, Ildiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298462/ https://www.ncbi.nlm.nih.gov/pubmed/22296763 http://dx.doi.org/10.1186/1477-3155-10-7

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