Cargando…

Effect of prolonged standardized bed rest on cystatin C and other markers of cardiovascular risk

BACKGROUND: Sedentary lifestyle is associated with coronary artery disease but even shorter periods of physical inactivity may increase cardiovascular risk. Cystatin C is independently associated with cardiovascular disease and our objective was to investigate the relation between this novel biomark...

Descripción completa

Detalles Bibliográficos
Autores principales: Arinell, Karin, Christensen, Kjeld, Blanc, Stéphane, Larsson, Anders, Fröbert, Ole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298483/
https://www.ncbi.nlm.nih.gov/pubmed/22152087
http://dx.doi.org/10.1186/1472-6793-11-17
_version_ 1782226003583565824
author Arinell, Karin
Christensen, Kjeld
Blanc, Stéphane
Larsson, Anders
Fröbert, Ole
author_facet Arinell, Karin
Christensen, Kjeld
Blanc, Stéphane
Larsson, Anders
Fröbert, Ole
author_sort Arinell, Karin
collection PubMed
description BACKGROUND: Sedentary lifestyle is associated with coronary artery disease but even shorter periods of physical inactivity may increase cardiovascular risk. Cystatin C is independently associated with cardiovascular disease and our objective was to investigate the relation between this novel biomarker and standardized bed rest. Research of immobilization physiology in humans is challenging because good biological models are in short supply. From the Women International Space simulation for Exploration study (WISE) we studied markers of atherosclerosis and kidney function, including cystatin C, in a standardized bed rest study on healthy volunteers. Fifteen healthy female volunteers participated in a 20-day ambulatory control period followed by 60 days of bed rest in head-down tilt position (-6°) 24 h a day, finalized by 20 days of recovery. The subjects were randomized into two groups during bed rest: a control group (n = 8) that remained physically inactive and an exercise group (n = 7) that participated in both supine resistance and aerobic exercise training. RESULTS: Compared to baseline values there was a statistically significant increase in cystatin C in both groups after bed rest (P < 0.001). Glomerular filtration rate (GFR), calculated by both cystatin C and Cockcroft-Gault equation, decreased after bed rest while there were no differences in creatinine or creatine kinase levels. CRP did not change during bed rest in the exercise group, but there was an increase of CRP in the control group during recovery compared to both the baseline and the bed rest periods. The apo-B/apo-Ai ratio increased during bed rest and decreased again in the recovery period. Subjects experienced a small but statistically significant reduction in weight during bed rest and compared to baseline weights remained lower at day 8 of recovery. CONCLUSION: During and following prolonged standardized bed rest the concentrations of several clinically relevant cardiovascular risk markers change.
format Online
Article
Text
id pubmed-3298483
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-32984832012-03-12 Effect of prolonged standardized bed rest on cystatin C and other markers of cardiovascular risk Arinell, Karin Christensen, Kjeld Blanc, Stéphane Larsson, Anders Fröbert, Ole BMC Physiol Research Article BACKGROUND: Sedentary lifestyle is associated with coronary artery disease but even shorter periods of physical inactivity may increase cardiovascular risk. Cystatin C is independently associated with cardiovascular disease and our objective was to investigate the relation between this novel biomarker and standardized bed rest. Research of immobilization physiology in humans is challenging because good biological models are in short supply. From the Women International Space simulation for Exploration study (WISE) we studied markers of atherosclerosis and kidney function, including cystatin C, in a standardized bed rest study on healthy volunteers. Fifteen healthy female volunteers participated in a 20-day ambulatory control period followed by 60 days of bed rest in head-down tilt position (-6°) 24 h a day, finalized by 20 days of recovery. The subjects were randomized into two groups during bed rest: a control group (n = 8) that remained physically inactive and an exercise group (n = 7) that participated in both supine resistance and aerobic exercise training. RESULTS: Compared to baseline values there was a statistically significant increase in cystatin C in both groups after bed rest (P < 0.001). Glomerular filtration rate (GFR), calculated by both cystatin C and Cockcroft-Gault equation, decreased after bed rest while there were no differences in creatinine or creatine kinase levels. CRP did not change during bed rest in the exercise group, but there was an increase of CRP in the control group during recovery compared to both the baseline and the bed rest periods. The apo-B/apo-Ai ratio increased during bed rest and decreased again in the recovery period. Subjects experienced a small but statistically significant reduction in weight during bed rest and compared to baseline weights remained lower at day 8 of recovery. CONCLUSION: During and following prolonged standardized bed rest the concentrations of several clinically relevant cardiovascular risk markers change. BioMed Central 2011-12-09 /pmc/articles/PMC3298483/ /pubmed/22152087 http://dx.doi.org/10.1186/1472-6793-11-17 Text en Copyright ©2011 Arinell et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Arinell, Karin
Christensen, Kjeld
Blanc, Stéphane
Larsson, Anders
Fröbert, Ole
Effect of prolonged standardized bed rest on cystatin C and other markers of cardiovascular risk
title Effect of prolonged standardized bed rest on cystatin C and other markers of cardiovascular risk
title_full Effect of prolonged standardized bed rest on cystatin C and other markers of cardiovascular risk
title_fullStr Effect of prolonged standardized bed rest on cystatin C and other markers of cardiovascular risk
title_full_unstemmed Effect of prolonged standardized bed rest on cystatin C and other markers of cardiovascular risk
title_short Effect of prolonged standardized bed rest on cystatin C and other markers of cardiovascular risk
title_sort effect of prolonged standardized bed rest on cystatin c and other markers of cardiovascular risk
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298483/
https://www.ncbi.nlm.nih.gov/pubmed/22152087
http://dx.doi.org/10.1186/1472-6793-11-17
work_keys_str_mv AT arinellkarin effectofprolongedstandardizedbedrestoncystatincandothermarkersofcardiovascularrisk
AT christensenkjeld effectofprolongedstandardizedbedrestoncystatincandothermarkersofcardiovascularrisk
AT blancstephane effectofprolongedstandardizedbedrestoncystatincandothermarkersofcardiovascularrisk
AT larssonanders effectofprolongedstandardizedbedrestoncystatincandothermarkersofcardiovascularrisk
AT frobertole effectofprolongedstandardizedbedrestoncystatincandothermarkersofcardiovascularrisk