Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells

Background: Platelet activation by collagen depends on signals transduced by the glycoprotein (GP)VI–Fc receptor (FcR)γ-chain collagen receptor complex, which involves recruitment of phosphatidylinositol 3-kinase (PI3K) to phosphorylated tyrosines in the linker for activation of T cells (LAT). An in...

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Detalles Bibliográficos
Autores principales: Moraes, L A, Barrett, N E, Jones, C I, Holbrook, L M, Spyridon, M, Sage, T, Newman, D K, Gibbins, J M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Platelets
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298659/
https://www.ncbi.nlm.nih.gov/pubmed/20723025
http://dx.doi.org/10.1111/j.1538-7836.2010.04025.x

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