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A 7 Tesla fMRI Study of Amygdala Responses to Fearful Faces

The amygdalae are involved in the perception of emotions such as happiness, anger and fear. Because of their proximity to the sinuses, the image signal intensity in T2* weighted fMRI data is often affected by signal loss due to through-slice dephasing, especially at high field strength. In this stud...

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Autores principales: van der Zwaag, Wietske, Da Costa, Sandra E., Zürcher, Nicole R., Adams, Reginald B., Hadjikhani, Nouchine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298740/
https://www.ncbi.nlm.nih.gov/pubmed/22270846
http://dx.doi.org/10.1007/s10548-012-0219-0
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author van der Zwaag, Wietske
Da Costa, Sandra E.
Zürcher, Nicole R.
Adams, Reginald B.
Hadjikhani, Nouchine
author_facet van der Zwaag, Wietske
Da Costa, Sandra E.
Zürcher, Nicole R.
Adams, Reginald B.
Hadjikhani, Nouchine
author_sort van der Zwaag, Wietske
collection PubMed
description The amygdalae are involved in the perception of emotions such as happiness, anger and fear. Because of their proximity to the sinuses, the image signal intensity in T2* weighted fMRI data is often affected by signal loss due to through-slice dephasing, especially at high field strength. In this study, the feasibility of fMRI in the amygdalae at 7 Tesla was investigated. A paradigm based on the presentation of fearful faces was used for stimulation. Previously, opposite effects have been found for presentation of averted and direct gaze fearful faces. Here, we show that (1) sufficiently high temporal SNR values are reached in the amygdalae for detection of small BOLD signal changes and (2) that the BOLD signal in the amygdalae for presentation of a direct or averted gaze in a fearful face depends on stimulus duration.
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spelling pubmed-32987402012-03-21 A 7 Tesla fMRI Study of Amygdala Responses to Fearful Faces van der Zwaag, Wietske Da Costa, Sandra E. Zürcher, Nicole R. Adams, Reginald B. Hadjikhani, Nouchine Brain Topogr Brief Communication The amygdalae are involved in the perception of emotions such as happiness, anger and fear. Because of their proximity to the sinuses, the image signal intensity in T2* weighted fMRI data is often affected by signal loss due to through-slice dephasing, especially at high field strength. In this study, the feasibility of fMRI in the amygdalae at 7 Tesla was investigated. A paradigm based on the presentation of fearful faces was used for stimulation. Previously, opposite effects have been found for presentation of averted and direct gaze fearful faces. Here, we show that (1) sufficiently high temporal SNR values are reached in the amygdalae for detection of small BOLD signal changes and (2) that the BOLD signal in the amygdalae for presentation of a direct or averted gaze in a fearful face depends on stimulus duration. Springer US 2012-01-22 2012 /pmc/articles/PMC3298740/ /pubmed/22270846 http://dx.doi.org/10.1007/s10548-012-0219-0 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Brief Communication
van der Zwaag, Wietske
Da Costa, Sandra E.
Zürcher, Nicole R.
Adams, Reginald B.
Hadjikhani, Nouchine
A 7 Tesla fMRI Study of Amygdala Responses to Fearful Faces
title A 7 Tesla fMRI Study of Amygdala Responses to Fearful Faces
title_full A 7 Tesla fMRI Study of Amygdala Responses to Fearful Faces
title_fullStr A 7 Tesla fMRI Study of Amygdala Responses to Fearful Faces
title_full_unstemmed A 7 Tesla fMRI Study of Amygdala Responses to Fearful Faces
title_short A 7 Tesla fMRI Study of Amygdala Responses to Fearful Faces
title_sort 7 tesla fmri study of amygdala responses to fearful faces
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298740/
https://www.ncbi.nlm.nih.gov/pubmed/22270846
http://dx.doi.org/10.1007/s10548-012-0219-0
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