Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor

BACKGROUND: Traumatic brain injury (TBI) induces activation of microglia. Activated microglia can in turn increase secondary injury and impair recovery. This innate immune response requires hours to days to become fully manifest, thus providing a clinically relevant window of opportunity for therape...

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Detalles Bibliográficos
Autores principales: d'Avila, Joana C, Lam, Tina I, Bingham, Deborah, Shi, Jian, Won, Seok Joon, Kauppinen, Tiina M, Massa, Stephen, Liu, Jialing, Swanson, Raymond A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298794/
https://www.ncbi.nlm.nih.gov/pubmed/22335939
http://dx.doi.org/10.1186/1742-2094-9-31

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